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There is a clear trend in industry to eliminate fluorine from metallurgical slags. Regarding the continuous casting process, fluorine in mould powders is undesirable due to the following reasons: (i) evolves easily from slags producing health-injurious gaseous substances like hydrofluoric acid, (ii) creates problems for storage and utilization of solid waste, and (iii) causes machinery corrosion. A collaboration among universities, mould powder supplier, and steel producer was established, aiming for the development of a new F-free mould powder for billet casting. Firstly, technological parameters for a particular composition were determined: melting characteristics, viscosity, melting behavior, and crystallization tendency. Afterwards, industrial trials were performed in a Brazilian steelworks, doing some evaluations during the continuous casting process, such as DT between water cooling inlet and outlet, slag pool thickness, melting performance, powder consumption, Al 2 O 3 pick-up, and effect on SEN erosion. Comparable surface quality for the billets was obtained when using the F-free mould powder, since the amount of scrap produced during the rolling process was not critical.

Background:Piper ovatum (Piperaceae) has been used in traditional medicine for the treatment of inflammations and as an analgesic. Previous studies have showed important biological activities of the extracts and amides from P. ovatum leaves.Objective:In this study, a high-performance liquid chromatographic (HPLC) method was developed and validated for quantitative determination of the amides in different parts of Piper ovatum.Materials and Methods:The analysis was carried out on a Metasil ODS column (150 × 4.6 mm, 5μm) at room temperature. HPLC conditions were as follows: acetonitrile (A), and water (B), 1.0% acetic acid. The gradient elution used was 0–30 min, 0-60% A; 30–40 min, 60% A. Flow rate used was 1.0mL/min, and detection at 280nm.Results:The validation using piperlonguminine, as the standard, demonstrated that the method shows linearity (linear correlation coefficient = 0.998), precision (relative standard deviation <5%) and accuracy (mean recovery = 103.78%) in the concentration range 31.25 – 500μg/mL. The limit of detection and quantification were 1.21 and 4.03μg/mL, respectively. This method allowed the identification and quantification of piperlonguminine and piperovatine in the hydroethanolic extracts of P. ovatum obtained from the leaves, stems and roots. All the extracts showed the same chromatographic profile. The leaves and roots contained the highest concentrations of piperlonguminine and the stems and leaves showed the most concentrations of piperovatine.Conclusion:This HPLC method is suitable for routine quantitative analysis of amides in extracts of Piper ovatum and phytopharmaceuticals containing this herb.