No abstract

BACKGROUND AND PURPOSE: Stent-supported aneurysm coiling has been utilized with increasing frequency over the past few years, particularly for addressing treatment of complex and wide-neck aneurysms. A sizable body of literature describing various experiences with stent-supported coiling now exists. The purpose of this research was to carry out a comprehensive literature survey of stent-supported aneurysm coiling.

Background: Between 9% and 23% of patients undergoing otherwise uncomplicated carotid endarterectomy (CEA) develop subtle cognitive decline 1 month postoperatively. The APOE-ε4 allele has been associated with worse outcome following stroke. Objective: To investigate the ability

. disclosure Dr. Becske is a consultant/proctor in the use of the Pipeline Embolization Device for Covidien. Dr. Saatci's institution received fees for participation in review activities from Chestnut Medical, and she received consultancy fees from ev3/Covidien. Dr. McDougall received consultancy fees from the Covidien Medical Advisory Board. Dr. Szikora and his institution received consulting fees or honoraria from Chestnut Medical, and he received consultancy fees from Stryker Neurovascular and ev3/ Covidien and speaker's and service fees for being on speakers' bureaus of Stryker Neurovascular and ev3/Covidien. Dr. Lanzino's institution received consulting fees or honoraria from ev3/Covidien and support for travel to meetings for the study or other purposes from ev3/Covidien for presentation to a FDA panel; his institution received an unrestricted educational grant from ev3/Covidien. Dr. Moran is a chief medical officer for Covidien, and he received fees from ev3/Covidien for lectures and for development of educational presentations. Dr. Woo's institution received funds for grants or for pending grants from Siemens and from MicroVention; he received royalties paid by Codman and Shurtleff for an acute stroke device after acquisition of Revasc and travel/accommodations/meeting expenses unrelated to this study from Siemens; and he is the President/CFO of Vascular Simulations. Dr. Berez was an employee of Chestnut Medical and ev3/Covidien and received patent royalties from Covidien; he has stock/stock options in Chestnut Medical and Covidien, and is a founder and employee of Chestnut; he received

This research communicates the authors' experience in developing a largely single-stage strategy for embolization of bAVMs. The results suggest that an aggressive, single-stage embolization may be implemented with a margin of safety and effectiveness similar to the multistage approaches more commonly reported in the literature. This work additionally introduces the importance of prospective assignment to a treatment strategy in assessing procedural outcome in bAVM embolization, thereby improving generalizability of the results and allowing for more rigorous interpretation of efficacy and safety.