Morbidity due to Corynebacterium pseudotuberculosis infection occurred in a 320 Holstein dairy herd in south-eastern Bulgaria during 2014. All established cases (n=43) were of multiple abscess formation and cellulitis predominantly localised on the hindlegs. The pyogranulomatous and ulcerative lesions in all cases were associated with mastitis. The disease was treated with parenteral antibiotics and local antiseptics, without any satisfactory outcome, and most of the affected animals were culled. Presumptive laboratory diagnosis of C pseudotuberculosis was made in November 2014, when 43 cases (herd prevalence 23.9 per cent) were recorded on the farm. The culling rate reached 95.3 per cent. All reported cases were in first calving cows (n=31; case prevalence 72.1 per cent), and cows between second and fifth lactation (n=12; case prevalence 27.9 per cent). Younger cattle appeared to be less susceptible to the infection. In first calving cows, all cases with lesions and mastitis occurred shortly after calving.