Transforming our world: the 2030 Agenda for Sustainable Development" was agreed upon in 2015 by the global community and proposes 17 Sustainable Development Goals (SDG) for the period between 2015 and 2030. Since the greater integration of goals was an explicit claim, there are numerous overlaps among them. One of the novelties of the SDGs is that, in order to achieve the set goals, the Agenda 2030 addresses not only the states but the businesses as well. In our study, the relationships between the SDGs were analyzed on the base of the Global Reporting Initiative (GRI) indicators linked to the goals. The analysis was carried out by cluster analysis. Our results indicate that there is a strong relationship to be found among nine of the 17 SDGs. That relationship is mainly technical, which is caused by the number of aligned (genuine) GRI indicators. Though there are relationships between the SDGs as well, their strength is much weaker. According to our classification of SDGs, we suggest that the gap of business attention among SDGs is smaller than it is showed by KPMG.

No abstract

No abstract

A policentrikus térszerkezet megteremtése iránti igény az Európai Unió fejlesztési dokumentumaiban egyre erőteljesebben fogalmazódik meg. A tudományos műhelyek, területi tervezéssel foglalkozó intézmények és vállalkozások minderre reagáltak, ma már a közösség nemzetállamai kormányzati szinten is foglalkoznak a kérdéssel. A tanulmány célja, hogy elhelyezze a policentrizmus koncepcióját a területi tervezés gyakorlatában, ezt követően pedig ismertesse gyakorlati vonatkozásait, a továbbfejlesztés irányait. Nem kérdéses, hogy az érintett politikai területek miatt a jövőben is vitákat fognak gerjeszteni az egyes országok települési szerkezetének aktív átalakítását célzó elképzelések.

Mycoplasma pneumoniae is the leading cause of bacterial community-acquired pneumonia among hospitalized children in the United States. It is also responsible for a spectrum of other respiratory tract disorders and extrapulmonary manifestations in children and adults. The main virulence factor of M. pneumoniae is a 591 amino acid multifunctional protein called Community Acquired Respiratory Distress Syndrome (CARDS) toxin. The amino terminal region of CARDS toxin (N-CARDS) retains ADP-ribosylating activity and the carboxy region (C-CARDS) contains the receptor binding and vacuolating activities. After internalization, CARDS toxin is transported in a retrograde manner from endosome through the Golgi complex into the endoplasmic reticulum. However, the mechanisms and criteria by which internalized CARDS toxin is transported and activated to execute its cytotoxic effects remain unknown. In this study, we used full-length CARDS toxin and its mutant and truncated derivatives to analyze how pharmacological drugs that alter pH of intracellular vesicles and electrical potential across vesicular membranes affect translocation of CARDS toxin in mammalian cells. Our results indicate that an acidic environment is essential for CARDS toxin retrograde transport to endoplasmic reticulum. Moreover, retrograde transport facilitates toxin clipping and is required to induce vacuole formation. Additionally, toxin-mediated cell vacuolation is strictly dependent on the function of vacuolar type-ATPase.