This study presents data comparing the bioavailability of DHA and EPA delivered by two different formulations: One group received TAG fish oil in traditional soft gel capsules, whereas the other group received the TAG oil as droplets trapped inside a gelatin matrix (gelled emulsions). The incremental area under the curve (AUC 0-26 h ) of EPA and EPA þ DHA in blood plasma from the gelled emulsions was significantly increased by 44.9 and 43.3%, respectively, compared to soft gel capsules. The maximum incremental concentration of EPA and EPA þ DHA was significantly increased by 100.4 and 105.6%, respectively, compared to soft gel capsules. These results suggest that improved bioavailability of EPA and DHA may be achieved by incorporating emulsified TAG fish oil in a gel matrix prior to oral ingestion.Practical applications: This study presents a new type of vehicle for the delivery of PUFAs. The vehicles are soft and chewable with the possibility of adding flavours, sweeteners and colour, and this makes the vehicles ideal for delivery of PUFAs to consumers having problems swallowing large capsules or cod liver oil. The vehicles are already applied in products in several countries, including Norway.

A bilateral approach for laser microsurgical posterior cordectomy combines excellent airway improvement and satisfactory voice preservation. In bilateral vocal fold paralysis, pretreatment and posttreatment clinical data should be evaluated by objective measures.

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Abstract:A method for repeatable loading of propranolol hydrochloride as a model drug onto the ion exchanger Amberlite TM IRP69 was developed and different parameters for the loading process were evaluated due to their impact of the extent of loading. It was found that the extent of loading in equilibrium is widely independent of the experimental method used. However, a magnetic stirrer comminutes the ion exchanger particles, which hampers repeatable loading processes. For kinetic studies, it was found that the pharmacopoeia dissolution tester gives best repeatable results compared to other stirring devices (magnetic stirrer or shaking bath). Furthermore, evaluation of the loading profiles revealed complex kinetics, which can be best described by (at least) two independent processes. In addition, with different ratios between ion exchanger and propranolol, the degree of loading in the equilibrium follows an adsorption isotherm of the Langmuir type, and predicts loading capacity.