The objective of this study was to describe the functional profiles of patients with Parkinson's disease (PD), and the relationships between impairment in body functions, limitations in activities, and environmental factors, using the World Health Organization's International Classification of Functioning, Disability, and Health (ICF). Patients were consecutively enrolled, and the ICF checklist was administered. Two count-based indices were developed: 'extension', containing ICF categories rated with qualifiers 1-4 and 'severity', containing ICF categories rated with qualifiers 3-4. Categories rated with qualifiers 1-4 in at least 50% of patients are described separately. Spearman's correlation analysis was carried out to identify the relationships between impairments in body functions (BF) and body structures, activities and participation, and environmental factors (EF); linear regressions were performed to identify the best predictors of performance indices in activities and participation. A total of 96 patients were enrolled; 34 categories rated with qualifiers 1-4 in at least 50% of patients are reported, and most of them describe impairment in movement-related functions and limitations in mobility and self-care. Performance indices are significantly lower than capacity and significant relationships with both BF impairments and EF are observed. High difficulties in activities and participation performance are connected with both presence of severe BF symptoms and relevant barriers in EF. Both BF and EF play a relevant role in improving functioning of the patients with PD. The connection between EF barriers and severe problems in activities and participation performance suggests the need of fostering participation of patients with PD by promoting facilitators among EFs. Methodologies and tools are needed to couple information on symptoms, on the difficulties in executing activities, and on environmental features.

We reported information on a broad set of domains, expanding migraine-specific ones, such as pain and lost workdays that were previously reported in other studies. Our results enable to enlarge the perspective of disability in patients with migraine, considering both symptoms, activities and the role of environmental factors.

Our study provided a description of functioning and disability domains in migraine, MG and PD and enabled to report the impact of EF in determining the actual disability experience.

The International Classification of Functioning, Disability, and Health Brief Core Set for Stroke reports accurately on the main problematic areas of functioning and activities of daily living of people after stroke. It is a brief and useful instrument to use in clinical practice and it can be proposed as a "starting point" to plan interventions and organize services for patients after stroke.

To describe the functional profiles of patients with migraine, and the relationships between symptoms, activities and environmental factors, using WHO's International Classification of Functioning (ICF). Patients were consecutively enrolled at the Besta Institute of Milan. The ICF checklist was administered and two count-based indexes developed: 'extension', containing ICF categories rated with qualifiers 1-4, and 'severity', containing ICF categories rated with qualifiers 3-4. Categories rated with qualifiers 1-4 in at least 50% of patients are described separately. Spearman's correlation was performed to identify the relationships between symptoms, activities and environmental factors; linear regressions were performed to identify the best predictors of performance indexes in activities and participation domain. One hundred and two patients joined this study. Twenty-eight categories rated with qualifiers 1-4 in at least 50% of patients are reported: they include difficulties in daily activities, in mobility and in labor activities. Capacity and performance indexes are significantly different. Low correlations are reported between body functions impairments and limitations in activities and participation, slightly higher with capacity indexes. Environmental factors are mildly correlated with capacity indexes. Environmental factors play a relevant role in improving functioning of patients with migraine. Nevertheless, difficulties in activities and participation are explained more by functional impairments than by the effect of environmental factors: in particular, no facilitators target difficulties in work activities or mobility. To plan appropriate interventions that meet patients' needs, especially in the labor sector, methodologies and tools are needed to couple information on symptoms, on the difficulties in executing activities and on environment's features.