Purpose: In chronic myelogenous leukemia (CML), leukemic stem cells (LSC) represent a critical target of therapy. However, little is known about markers and targets expressed by LSCs. The aim of this project was to identify novel relevant markers of CML LSCs.Experimental Design: CML LSCs were examined by flow cytometry, qPCR, and various bioassays. In addition, we examined the multipotent CD25 þ CML cell line KU812.

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The high variability and low heat of fusion of composite shape-stabilized phase change materials is a considerable challenge to their widespread application. Here we present the synthesis of shape-stabilized phase change materials composed of lauric acid and mesoporous silica with high heat of fusion through evaporative solution impregnation. Two hexagonal ordered silica with 2.8 and 6.3 nm pores (MCM-41, SBA-15) and two disordered mesocellular foams with 27 -34.9 nm spherical pores connected by 10.4 -14.9 nm "windows" are employed.The thermal properties and stability, heat storage efficiency, crystallization, textural and chemical properties are investigated using DSC analysis, small-and wide-angle XRD, nitrogen adsorption-desorption isotherms, optical and electron microscopy, as well as FT-IR spectroscopy. MCF-based materials with up to 83% wt. fatty acid show large latent heat (124 Jg -1 ), almost 90% efficiency with respect to the acid content and two melting -crystallization temperature ranges associated with nanoconfined and bulk phases. Up to 53 Jg -1 enthalpy change for the nanoconfined phase can be obtained. The melting point depression, heat storage efficiency and the physical state of lauric acid at the mesopore level are correlated with theoretical considerations of thermodynamic and geometric factors, revealing a non-melting interface layer of one organic molecule thickness. This approach provides a facile methodology to estimate the relevant properties of mesoporous silica phase change materials with useful dual temperature ranges.

This study evidenced the nanoconfinement effect on polyphenolic extracts prepared from Salvia officinalis L. and Thymus serpyllum L. into the mesopores of silica and titania nanomaterials on their radical scavenging capacity and antimicrobial potential. The ethanolic and hydroalcoholic extracts obtained either by conventional or microwave-assisted extraction were characterized in terms of total polyphenols, total flavonoids, and chlorophyll content, as well as radical scavenging activity by consecrated spectrometric determinations. The phytochemical fingerprint of extracts was analyzed by high-performance liquid chromatography-photodiode array detector. Salvia officinalis extracts exhibited better radical scavenging capacity and antimicrobial potential than Thymus serpyllum extracts. The mesoporous MCM-41 silica and titania nanomaterials, prepared by the sol–gel method, were characterized by small- and wide-angle powder diffraction, FTIR spectroscopy, nitrogen adsorption–desorption isotherms, scanning electron microscopy and transmission electron microscopy, while the materials containing embedded extracts were analyzed through Fourier-transform infrared spectroscopy, N2 sorption measurements, and thermal analysis. All extracts free and embedded in mesoporous matrix exhibited high radical scavenger properties and good bactericidal activity against several reference strains. It was proved that by embedding the polyphenolic extracts into mesopores of silica or titania nanoparticles, the phytochemicals stability was enhanced as the materials containing extract exhibited higher radical scavenger activity after 3–6 months storage than that of the free extracts. Additionally, the extract-loaded material showed mild improved antimicrobial activity in comparison with the corresponding free extract.

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