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Extracts rich in bioactive compounds added to edible films have allowed the development of active packaging that increases the shelf life of food. However, it is necessary to search for solvents that are nontoxic and not harmful to the environment, with natural deep eutectic solvents (NADES) being an attractive and easily synthesized alternative. This research aimed to design NADES by lyophilization to be used in the extraction of anthocyanins from the Chilean Luma chequen (Molina) A. Gray berry, and subsequently adding them to the matrix of edible ƙ-carrageenan films. For this purpose, ultrasound-assisted extraction (UAE) was used and the anthocyanin content was evaluated with the pH differential method. The antioxidant capacity of extracts was determined by DPPH assay and the antibacterial capacity by diffusion agar tests. The results obtained indicate that the designed NADES are efficient at extracting anthocyanins, reaching concentrations between 81.1 and 327.6 mg eq cyanidin 3-glucoside/100 g dw of L. chequen (Molina) A. Gray. The extracts reached inhibition diameters between 5 and 34 mm against Escherichia coli, Staphylococcus aureus, and Salmonella typhi strains. Once the extracts were incorporated into ƙ-carrageenan films, active edible films with antioxidant and antibacterial capacities were obtained.

El objetivo de esta investigación fue estimar la vida útil de la uchuva por efecto de la aplicación de un recubrimiento a base de quitosano y áloe vera utilizando el método de aspersión. La Norma Técnica Colombiana (NTC 4580) se empleó para comparar las características físicas de las uchuvas, utilizando como indicadores de deterioro, pérdida de peso, carotenoides totales e índice de color. Las muestras evaluadas se mantuvieron a dos condiciones de almacenamiento; bajo refrigeración (4 °C) y a temperatura ambiente de la ciudad de Cali (28 °C), durante un periodo de 21 y 6 días, respectivamente. Cuatro uestreos se realizaron para cada temperatura y los resultados obtenidos se utilizaron para definir la cinética de deterioro. La cinética fue de orden cero, siendo la pérdida de peso el indicador que limitó el tiempo de vida útil. Las variables como pH, acidez e índice de madurez no mostraron diferencia significativa a un nivel de significancia p < 0,05. Finalmente, el modelamiento cinético para la pérdida de peso presentó un incremento de 1 día para las muestras almacenadas a temperatura ambiente y de 2 días para las muestras refrigeradas a 4 °C.

The objective of this study was to evaluate the effect of ciprofibrate on serum triglyceride concentrations in canine patients. A sample size of 21 canines was study, that had a diagnosis of familial dyslipidemia, and was established with triglyceride levels above 500mg/dl, treatment with ciprofibrate was evaluated at 2 months. The analysis of the variation in triglyceride levels was performed using the non-parametric Wilcoxon matched-pairs signed-rank test. The Wilcoxon test revealed that the triglyceride concentration decreased significantly after two months of treatment with ciprofibrate; from 621 (512 to 1046)mg/dL to 136 (67 to 215)mg/dL (p <0.0001). The difference in medians was -482.0md/dL with a 97.3% confidence interval of -579.0 to -443.0mg/dL. It was concluded that the use of drugs such as ciprofibrate in the treatment of patients with familial hiperlipidemia, had a significant decrease in serum triglyceride concentrations, without generating adverse reactions in this study.