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Vaccination against COVID-19 is a key preventive measure to reduce the rate of infection, contribute to herd immunity and reduce the severity of the clinical presentation. Objectives: To investigate the acceptance of vaccination against COVID-19 and the determining factors in users from 18 years of age in the Urban Ambulatory type I "El Ujano" in Barquisimeto, Venezuela. Methods: A cross-sectional descriptive study was conduced with an accidental non-probabilistic sample made up of 276 users in October-November 2021. The collection technique used was the guided interview and a structured questionnaire was formulated as a data collection tool. The analysis was descriptive, using absolute and relative frequency measures. Results: 87,3 % accepted the vaccine, prevailing in both sexes and all age groups. Regardless of the level of education of the respondents, the high level of knowledge about COVID-19 and its prevention prevailed in 60,2 %. The main source of information was television (54,8 %). The presence of a pathological history of infection by personal, family or known COVID-19 was demonstrated

In this report, we show that murine and human saliva contains gut peptide YY (PYY3‐36), a hormone characterized by its physiological function of increasing satiation but not altering appetite. The purpose of the study was to investigate whether changes in salivary PYY3‐36 concentration induced either pharmacologically (acute augmentation) or genetically (gene therapy) would modulate food intake (FI) and body weight (BW) in C57Bl6 mice. Short‐term augmentation resulted in transient decrease in FI followed by compensatory feeding. On the contrary, sustained PYY transgene expression in the salivary gland resulted in a significant reduction of FI and 24% decrease of BW in diet‐induced obese mice over the eight weeks study. A conditioned taste aversion (CTA) test was used to determine the mechanism of FI reduction. Intra‐peritoneal administration of PYY3‐36, or LiCl produced CTA to the paired flavored chow, whereas no such response was documented in response to the augmentation of the salivary PYY3‐36. Furthermore, hypothalamic c‐fos activation had been investigated in response to the acute salivary PYY3‐36 augmentation. Interestingly, the treatment induced hypothalamic nuclei similar to the ones activated during re‐feeding. In conclusion, we describe the existence of an alternative satiation pathway mediated by salivary PYY3‐36 suggesting novel pharmacological and/or genetic approaches to treat obesity.

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