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The screening of four invasive plant species for use as biocatalysts in the stereoselective reduction of ketones is reported. Our studies revealed that fruits of Ligustrum lucidum can be used for the bioreduction of acetophenone to ( S )-1-phenylethanol (94% conversion, Ͼ 99 enantiomeric excess [ee]%). Using this methodology, 13 substituted ( S )-phenylethanols were synthesized with good ee values ( Ͼ 99.9 to 78%) using a technique which is more environmentally friendly than classical reduction of prochiral ketones. The results reveal the fruits of L. lucidum to be promising biocatalysts for the production of key intermediates.

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Kinetic profiles of the stereoselective reduction of acetophenone and its derivatives promoted by Galactomyces candidus GZ1. A mechanistic interpretation, Biocatalysis and Agricultural Biotechnology,

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