The goal of the present study is to analyze the complex economic processes within emerging territorial systems, developed around big cities. Economic ventures concentrated inside these urban clusters in a short span of time, and they registered a spectacular evolution, compared to the neighboring areas. Intensification of the linkages between cities with more than 300,000 inhabitants in Romania and the surrounding areas led to the individualization of territorial systems apart, with a spectacular evolution of economic-social processes, which turn those systems into the most dynamic territorial structures. The present study means to identify the causes of those complex processes within emerging territorial systems, the manner of functional organization of the space, and the causes that determine the spectacular evolution of the economic processes within emerging systems.

The application of geographical information systems (GIS) to the assessment of accessibility to hospitals has been investigated for an important growth pole in SouthEast Europe, respectively Bucharest and its metropolitan area. The calculation of accessibility at an intra-regional level is essential, taking into consideration the major role as a capital city, as well as the magnitude of the influence exercised over its hinterland. The territorial dynamics, characterizing a metropolis and also the attraction on a constant number of people, may raise a number of issues such as overcrowding of the main access roads into the city, the pressure put on the public transportation network, the rise of the number of personal cars, which is linked to the longer time needed to travel to various services areas.

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Objectives. Neurofibromatosis type 1 (NF1) is a multisystem genetic neurocutaneous disease, with an autosomal dominant inheritance, affecting in a various degree the skin, the bones and also the nervous system. The neurological manifestation of this condition are due to peripheral nerves and also to associated brain lesions. Epilepsy can be one of the symptoms within NF1, with a double prevalence compared to the general population. The connection between seizures and neurofibromatosis type 1 is a clinically observable reality. Methods. This paper is a retrospective observational study over a period of 4 years of children admitted to pediatric neurology clinic with a diagnosis of NF1. Clinical (neurological symptoms, such as seizures, their onset, psychiatric and cognitive profile) and laboratory data (routine electroencephalography, brain imaging exams) were analyze in order to find a cause-effect relation of this association and also the evolution predictive factors. Results. There were evaluated 67 children with a diagnose of NF1 according to existing diagnostic criteria (1), and the association between epilepsy and neurofibromatosis type 1 has been reported in 4 patients, 2 boys and 2 girls. The onset of seizures had an average age of 36 months. 2 patients had drug resistant focal seizures associated with moderate and severe mental retardation. Cerebral magnetic resonance imaging (MRI), showed typical hyperintense lesions for this neurocutaneous syndrome only in 50% of cases. Conclusions. The article will present clinical and laboratory correlations between the association of seizures and neurofibromatosis in these 4 children, with reference to data published in the literature in this area.