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In order to obtain a personalized three-dimensional model of a patient based on CT images, the InVesalius program was initially used, which performs the initial conversion of the analyzed tissues into a specific engineering file composed of the so-called "point cloud". This "point cloud" was imported into the Geomagic program, in which, using reverse engineering techniques, the "point cloud" was initially transformed into elementary triangular surfaces. These primary geometric structures have been edited, transformed, adapted so that, in the end, perfectly closed surfaces are obtained. It was done in this way, both for the bone structure of the head, but also for the dental structure. These complex geometries were loaded into SolidWorks, where they were originally transformed into virtual solids. These geometric structures were loaded and assembled into SolidWorks and interference solids were removed. Finally, a customized three-dimensional model was obtained on which different normal or pathological situations can be analyzed using kinematic simulations or using the finite element method.

Background: Cystic fibrosis (CF) is the most common monogenic disease, characterized by clinically notable polymorphism. Respiratory disease is the main factor that influences the disease outcome and prognosis of the patient with CF, bacterial infections being responsible for severe exacerbations and rhinosinusitis a difficult complication, besides lung disease. Aim: The aim of the paper was to present a case series of CF-associated nasal polyposis and our management experience, providing new data for nasal and sinus complications. Patients, Materials and Methods: Patients attending the National Cystic Fibrosis Center, Timişoara, Romania, were evaluated for nasal polyposis. Besides clinical examination, endoscopy, and computed tomography (CT) was performed for comprehensive evaluation. Patients with persistent symptoms or with complicated sinusitis underwent surgical approach. Results: Fourteen (18.18%) children were diagnosed with nasal polyposis and had surgery, with positive outcomes. One patient received Omalizumab for an associated, uncontrolled asthma with a subsequent substantial effect with the significant polyp reduction and lack of recurrence. Conclusions: Even if extremely difficult to manage, complicated nasal polyposis CF related might have an improved outcome and better life quality.