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Purpose International sales are critical for the prosperity of small and medium enterprises (SMEs), because of the limited size of their domestic market, but they can be difficult to attain for a number of reasons. The purpose of this paper is to investigate this topic and use a domain ambidexterity framework to analyze why the relationship between research and development (R&D) investments and export initiatives generates managerial tensions in high- and medium-technology industries. In this paper, it is claimed that R&D investments and internationalization can be conflicting objectives that entail a diversity of routines and managerial approaches. This aspect is critical, especially when SMEs are in the early stages of their life cycle and are resource constrained. Design/methodology/approach This issue is tested using multiple regressions on data collected through a survey that was conducted in 2014. The sample is composed of 221 SMEs operating in Italy in high-and medium-technology industries. Findings The estimates show that combining contemporary high R&D investments and high export activities negatively affects the growth of revenues of SMEs. In detail, when exports over revenue are below 10 percent, R&D investments have a positive effect on revenue growth, whereas when exports over revenue are above 50 percent, the effect of R&D investments on revenue growth is negative. However, age acts as a moderator on this relationship, thus implying that the effect of combining these initiatives varies according to the life cycle of a firm. In particular, combining R&D investments and export generates tensions that limit the growth of revenues in young SMEs (less than ten years old). For firms aged between 10 and 25 years, the effect is positive, while the effect is positive but not statistically significant for mature firms (older than 25 years). These results demonstrate that the diversity of the organizational maturity in SMEs has an impact on their ability to combine activities that require different capabilities (technological vs market). Originality/value This paper offers a theoretical contribution to the literature on domain ambidexterity, as it shows that combining contemporary innovation-related activities with international activities may constrain the performance of SMEs, according to the age of the firm. It extends the theoretical framework of domain ambidexterity to international studies and it reconciles previous mixed evidence about the combination of innovation and internationalization activities of SMEs.