Sharing and reusing anatomical models over the Web offers a significant opportunity to progress the investigation of cardiovascular diseases. However, the current sharing methodology suffers from the limitations of static model delivery (i.e. embedding static links to the models within Web pages) and of a disaggregated view of the model metadata produced by publications and cardiac simulations in isolation. In the context of euHearta research project targeting the description and representation of cardiovascular models for disease diagnosis and treatment purposes-we aim to overcome the above limitations with the introduction of euHeartDB, a Web-enabled database for anatomical models of the heart. The database implements a dynamic sharing methodology by managing data access and by tracing all applications. In addition to this, euHeartDB establishes a knowledge link with the physiome model repository by linking geometries to CellML models embedded in the simulation of cardiac behaviour. Furthermore, euHeartDB uses the exFormat-a preliminary version of the interoperable FieldML data format-to effectively promote reuse of anatomical models, and currently incorporates Continuum Mechanics, Image Analysis, Signal Processing and System Identification Graphical User Interface (CMGUI), a rendering engine, to provide three-dimensional graphical views of the models populating the database. Currently, euHeartDB stores 11 cardiac geometries developed within the euHeart project consortium.

The analysis of modern business processes implemented as orchestration of software services demands for new approaches that explicitly take into account the inherent complexity and distribution characteristics of such processes. In this respect, Distributed Simulation (DS) offers a viable tool to cope with such a demand, due to the aggregation, scalability, representativeness and load balancing properties that it allows to achieve. However, the use of DS is mostly limited by the specialized technical know-how and the extra-development that DS requires with respect to approaches based on conventional local simulation. This paper proposes a model-driven method that enables the DS-based analysis of business processes by introducing the automated transformation of business process models into analysis models that are specified as Extended Queueing Network (EQN) models and executed as distributed simulations. The paper also presents an example application to a business process for an e-commerce scenario.

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The development of complex systems requires the use of quantitative analysis techniques to allow a designtime evaluation of the system behavior. In this context, distributed simulation (DS) techniques can be effectively introduced to assess whether or not the system satisfies the user requirements. Unfortunately, the development of a DS requires the availability of an IT infrastructure that could not comply with time-to-market requirements and budget constraints. In this respect, this work introduces HLAcloud, a model-driven and cloud-based framework to support both the implementation of a DS system from a SysML specification of the system under study and its execution over a public cloud infrastructure. The proposed approach, which exploits the HLA (High Level Architecture) DS standard, is founded on the use of model transformation techniques to generate both the Java/HLA source code of the DS system and the scripts required to deploy and execute the HLA federation onto the PlanetLab cloud-based infrastructure

Simulation is a key technique for enabling business process analysts to predict the process behavior at design time. However, some issues limit the effectiveness of business process simulation (e.g., lack of simulation know how, costs and difficulties for gathering process data, semantic gap between the business process model and the simulation model). This paper proposes a model-driven method that automates the generation of executable business process simulation code. In order to address the increasing complexity and to take into account the inherent collaborative aspects of modern business processes, the simulation code produced by the proposed method replicates the business process distributed structure (in terms, e.g., of a service-oriented architecture) by including a set of simulation services that are orchestrated into a distributed simulation execution. The characterization of business processes in terms of the required performance properties is introduced through standard BPMN annotations according to a well-defined syntax, thus avoiding the need of additional languages. The implementation of the executable simulation code is based on the eBPMN language, a domain-specific language that preserves the semantic behavior of the original BPMN standard