This study outlines a procedure for the seismic safety evaluation of historical buildings for engineers and architects that commonly work on buildings belonging to cultural and architectural heritage. The procedure is characterized by two interrelated phases: (a) building knowledge acquisition and (b) structural behavior analysis and safety assessment. The seismic safety evaluation strongly depends on the first phase, whose data can be obtained according to a multi-disciplinary approach based on five steps: (1) critical-historical analysis; (2) photographic documentation and geometrical survey; (3) structural identification and material survey; (4) foundation and soil survey; and (5) cracking pattern and structural integrity analysis. The proposed method was applied to the evaluation of the seismic safety of the Castle of Melfi (PZ, Italy). Comprehensive and multi-disciplinary knowledge of this monument greatly facilitated an accurate seismic analysis of this monument, which was conducted both at a local and global level using a linear kinematic analysis and non-linear static (pushover) analysis, respectively.