Background : Hyperinsulinemic hypoglicemia with severe neuroglycopenic symptoms has been
identified as a late and rare complication in patients submitted to Roux-en-Y
gastric bypass. However, the potential gravity of its manifestations requires
effective treatment of this condition. The absence of treatment makes it necessary
to develop more effective clinical or surgical methods.
Aim : To present one surgical option to revisional surgery in the treatment of
hyperinsulinemic hypoglicemia
Methods : The procedure consists in reconstituting alimentary transit through the duodenum
and proximal jejunum, while keeping the restrictive part of the gastric bypass. As
an additional strategy to maintain weight loss, is realized gastric fundus
resection, aiming to suppress ghrelin production more effectively.
Results : It was used in three patients with successful results in one year of follow-up.
Conclusion : The procedure to reconstruct the food transit through the duodenum and proximal
jejunum, keeping the restrictive component of gastric bypass in the treatment of
hyperinsulinemic hypoglycemia showed good initial results and validated its
application in other cases with this indication.
Objectives: the surgical approach persists as the main treatment for esophageal cancer. This study compares the patients of the same institution over time at three different times. Methods: this is a retrospective, observational, descriptive study comparing the surgical outcomes obtained by the Division of Surgical Oncology of Erasto Gaertner Hospital. The sample was divided into Period 1 (1987-1997), Period 2 (1998-2003) and Period 3 (2007-2015). Survival rates and disease-free survival were estimated by the Kaplan-Maier method. Survival predictors were identified with Cox regression. ANOVA test was used for comparison between groups. Data were analyzed with SPSS 25.0 and STATA 16, and p<0.05 was considered statistically significant. Results: a total of 335 patients underwent esophagectomy or esophagogastrectomy. When the clinical characteristics of the 3 groups were compared, there was no statistically significant difference. Neoadjuvance was significantly higher in Period 3 (55.4% of patients). We found a histological change in the diagnosis over time, with a significant increase in adenocarcinoma. Morbidity and mortality rates were higher in Period 3. The main complications were pulmonary and anastomotic fistulas. Overall survival in 5 years increased over time, reaching 59.7% in Period 3. Conclusions: better neoadjuvant treatment contributed to increase the global survival of patients, despite greater rate of immediate complications to surgery.
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