No abstract

No abstract

BackgroundIt is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. The study aims to compare clinical characteristics and outcomes of COVID-19 patients with and without hypothyroidism.MethodsThe study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis, including data collected from 37 hospitals. Matching for age, sex, number of comorbidities and hospital was performed to select the patients without hypothyroidism for the paired analysis.ResultsFrom 7,762 COVID-19 patients, 526 had previously diagnosed hypothyroidism (50%) and 526 were selected as matched controls. The median age was 70 (interquartile range 59.0-80.0) years-old and 68.3% were females. The prevalence of underlying comorbidities were similar between groups, except for coronary and chronic kidney diseases, that had a higher prevalence in the hypothyroidism group (9.7% vs. 5.7%, p=0.015 and 9.9% vs. 4.8%, p=0.001, respectively). At hospital presentation, patients with hypothyroidism had a lower frequency of respiratory rate > 24 breaths per minute (36.1% vs 42.0%; p=0.050) and need of mechanical ventilation (4.0% vs 7.4%; p=0.016). D-dimer levels were slightly lower in hypothyroid patients (2.3 times higher than the reference value vs 2.9 times higher; p=0.037). In-hospital management was similar between groups, but hospital length-of-stay (8 vs 9 days; p=0.029) and mechanical ventilation requirement (25.4% vs. 33.1%; p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs. 27.0%; p=0.062).ConclusionIn this large Brazilian COVID-19 Registry, patients with hypothyroidism had a lower requirement of mechanical ventilation, and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis, and should not be considered among the comorbidities that indicate a risk factor for COVID-19 severity.

Background It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. Methods The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities and hospital was performed for the paired analysis. Results From 7,762 COVID-19 patients, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years-old and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in hypothyroid patients (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs. 27.0%; p=0.062). Conclusion Patients with hypothyroidism had a lower requirement of mechanical ventilation, and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.

Introdução: O uso das redes sociais como fonte de informação durante a pandemia de Covid-19 possibilitou o acesso do grande público a informações atualizadas, mas também permitiu uma intensa disseminação de notícias falsas no Brasil e no mundo. Objetivo: Este relatório tem como objetivo apresentar a experiência da tecnologia que possibilita a organização e implantação de um evento científico online gratuito de grande escala sobre a Covid-19, com foco em informações baseadas em evidências, atendimento e gestão do paciente. Métodos: O "Primeiro Congresso Brasileiro de Evidências Clínicas sobre Covid-19" aconteceu entre os dias 03 e 07 de maio de 2021 e foi realizado pela Universidade Federal de Minas Gerais, a principal universidade federal do Brasil. Resultados: Houve 27.102 cadastros. A transmissão teve 29.170 visualizações no primeiro dia. Em 25 de junho de 2021, foram 80.923 visualizações para a versão original em áudio e 10.352 visualizações para a tradução simultânea. Os tópicos compreenderam prevenção da Covid-19, gestão na atenção primária, atendimento pré-hospitalar, assistência hospitalar, unidade de terapia intensiva, longa-COVID-19, vacinas, saúde mental e custos. Minipalestras foram seguidas de discussão e interação com os participantes. Palestrantes e moderadores de todo o Brasil e do exterior foram escolhidos de acordo com sua expertise em temas de Covid-19 e em medicina baseada em evidências. Entre as sessões, foram apresentados depoimentos em vídeo de pessoas que não puderam trabalhar em casa sobre o que tocou seu coração durante a pandemia. A acessibilidade foi garantida por meio de tradução simultânea para a Língua Brasileira de Sinais. A satisfação dos participantes foi avaliada, com 2.228 respondentes, dos quais 97,4% disseram que suas expectativas foram superadas e 86,8% relataram adquirir novos conhecimentos sobre a Covid-19. Final considerations: Essa experiência mostrou que a tecnologia possibilitou a divulgação de evidências científicas acessíveis sobre a Covid-19 para um grande público por meio de um evento online gratuito.