Summary Preclinical data suggests anti‐lymphoma potential for statins, metformin and cyclooxygenase‐2 (COX‐2) inhibitors. We performed a retrospective population‐based study of all adults aged ≥66 years diagnosed with diffuse large B‐cell lymphoma (DLBCL) or transformed lymphoma treated with a rituximab containing regimen, between 2005 and 2015 in Ontario, Canada. Using administrative databases, we assessed the impact of medication exposures, prior to chemo‐immunotherapy, on lymphoma survival. Cox regression analyses, controlling for sociodemographic factors and comorbidities, examined the relationship between medication exposure and survival. In total, 4913 patients were treated with curative intent (median age 75 years, 51% male) and 52·2% died at a median of 1 year from treatment initiation (67% due to DLBCL). In the year prior to commencing treatment, 45·7% received statins, 16·3% metformin, and 25·0% a COX‐2 inhibitor. Adjusting for confounders, exposure to statin and COX‐2 inhibitors prior to chemo‐immunotherapy independently conferred a survival advantage: statin exposure for 30 days (hazard ratio [HR] 0·97, 95% confidence interval [CI] 0·96–0·98), 180 days (HR 0·84, 95% CI 0·80–0·89) and 365 days (HR 0·71, 95% CI 0·63–0·79) and COX‐2 inhibitor exposure for 30 days (HR 0·95, 95% CI 0·95–0·98), 180 days (HR 0·76, 95% CI 0·66–0·86) and 365 days (HR 0·57, 95% CI 0·43–0·74). Metformin had no significant impact. This population‐based study found a dose‐related survival benefit of exposure to statins and COX‐2 inhibitors prior to chemo‐immunotherapy for newly diagnosed DLBCL.

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Internet technologies are an increasingly necessary tool for sex working people, disabled people, and people who hold both identities to access resources, community, and income, as well as make claims to rights and fight for social justice. However, ongoing community research suggests that the failures of online platforms to address accessibility needs have had grave effects on sex workers, particularly those with disabilities. This article examines how normative whorephobic, racist, ableist user experience (UX) social media design intersects with punitive virtual content moderation systems to negatively impact disabled sex workers. To better understand how, we focus on unique problems faced by disabled people on the internet and how disability intersects with the sex trade and sexualization more broadly. We draw on data from our previous community research, Erased: The Impact of FOSTA-SESTA and the Removal of Backpage, in addition to Posting into the Void, to share experiences of sex workers navigating disability and discriminatory online systems. We highlight how whorephobic content moderation and punitive platform policing, exacerbated by FOSTA-SESTA, uniquely impact disabled sex workers, particularly those who depend on visual or aural aids to engage with social media. In doing so, we highlight critical intersections between disability justice, sex worker justice, and design justice to advocate for the importance of collaboration between movements.