An unprecedented C-H functionalization of aryldiazo compounds without a preinstallation of directing group has been realized under mild conditions, which differs from former reports in its use of diazo compounds as coupling partners in directed C-H activations. This novel transformation has been realized by a rhodium self-relay catalysis, a tandem process of the in situ formation of a directing group and sequential C-H bond activation.

The first gold-catalyzed highly regio- and enantioselective carbene insertion into the O-H bonds of 2-pyridones has been realized in the presence of catalytic amounts of chiral dual-gold complexes. The corresponding chiral products were obtained in moderate to good yields, excellent O-selectivity, excellent carbenic selectivity and moderate to excellent enantioselectivities (up to 96% ee).

A highly efficient rhodium-catalyzed C-H activation of arylhydrazines and coupling with internal alkynes has been realized under mild conditions. The isoquinolines have been prepared in moderate to excellent yields in high efficiency. This methodology features the use of readily available starting materials, and a simple hydrazine moiety as a directing group, in the absence of an external metal co-oxidant under an air atmosphere. The C-H bond activation and the N-N bond cleavage have been successively realized under mild conditions.

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An Efficient Synthesis of Isoquinolines via Rhodium-Catalyzed Direct C-H Functionalization of Arylhydrazines. -(ZHANG, S.; HUANG, D.; XU, G.; CAO, S.; WANG, R.; PENG, S.; SUN*, J.; Org. Biomol. Chem. 13 (2015) 29, 7920-7923, http://dx.doi.org/10.1039/C5OB01171J ; Sch. Pharm. Eng. Life Sci., Changzhou Univ., Changzhou 213164, Peop. Rep. China; Eng.) -M. Tismer 46-174