Dramatic results from recent animal experiments show that noise exposure can cause a selective loss of high-threshold auditory nerve fibers without affecting absolute sensitivity permanently. This cochlear neuropathy has been described as hidden hearing loss, as it is not thought to be detectable using standard measures of audiometric threshold. It is possible that hidden hearing loss is a common condition in humans and may underlie some of the perceptual deficits experienced by people with clinically normal hearing. There is some evidence that a history of noise exposure is associated with difficulties in speech discrimination and temporal processing, even in the absence of any audiometric loss. There is also evidence that the tinnitus experienced by listeners with clinically normal hearing is associated with cochlear neuropathy, as measured using Wave I of the auditory brainstem response. To date, however, there has been no direct link made between noise exposure, cochlear neuropathy, and perceptual difficulties. Animal experiments also reveal that the aging process itself, in the absence of significant noise exposure, is associated with loss of auditory nerve fibers. Evidence from human temporal bone studies and auditory brainstem response measures suggests that this form of hidden loss is common in humans and may have perceptual consequences, in particular, regarding the coding of the temporal aspects of sounds. Hidden hearing loss is potentially a major health issue, and investigations are ongoing to identify the causes and consequences of this troubling condition.

Human neuroimaging studies have identified a region of auditory cortex, lateral Heschl's gyrus (HG), that shows a greater response to iterated ripple noise (IRN) than to a Gaussian noise control. Based in part on results using IRN as a pitch-evoking stimulus, it has been argued that lateral HG is a general "pitch center." However, IRN contains slowly varying spectrotemporal modulations, unrelated to pitch, that are not found in the control stimulus. Hence, it is possible that the cortical response to IRN is driven in part by these modulations. The current study reports the first attempt to control for these modulations. This was achieved using a novel type of stimulus that was generated by processing IRN to remove the fine temporal structure (and thus the pitch) but leave the slowly varying modulations. This "no-pitch IRN" stimulus is referred to as IRNo. Results showed a widespread response to the spectrotemporal modulations across auditory cortex. When IRN was contrasted with IRNo rather than with Gaussian noise, the apparent effect of pitch was no longer statistically significant. Our findings raise the possibility that a cortical response unrelated to pitch could previously have been errantly attributed to pitch coding.

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Pitch is a fundamental auditory sensation, underlying both music and speech perception. This study was designed to explore pitch coding in human auditory cortex by testing whether activity in pitch-responsive regions covaries as a function of pitch salience (pitch strength). A psychophysical paradigm was used to confirm three levels of pitch salience for two different pitch-evoking stimuli. The location and magnitude of the response to these stimuli were measured using functional magnetic resonance imaging. A pitch response was found in planum temporale, close to the posterolateral border of Heschl's gyrus. However, the response was not sensitive to pitch salience. One interpretation is that pitch-sensitive regions are maximally responsive to the presence or absence of pitch and not to pitch salience.