Metabolic syndrome is an epidemic of XXI century. Each of the components of metabolic syndrome (arterial hypertension, hyperglycemia or dyslipidemia) can be a risk factor for chronic kidney disease. However, it remains unknown what plays a key role in the progression of the disease. The objective of the research was to identify early detectors of kidney damage in patients with metabolic syndrome. Materials and methods. The study involved 70 patients with metabolic syndrome. In addition to standard examination methods, markers of endothelial disfunction (hydrogen sulfide and nitrogen monooxide) were measured in venous blood samples and the urine was tested for microalbuminuria. All the patients were divided into 3 groups according to the degree of albuminuria: normoalbuminuria, microalbuminuria and macroalbuminuria. To compare the indices between the groups, the Student's t-test was used; to determine the relationship between the individual values, the Pearson correlation coefficient (r) was applied. Results. The indicator of systolic blood pressure was higher in patients with microalbuminuria compared to those with normoalbuminuria (163.4±14.4 mmHg, versus 153.0±17.7 mmHg; p<0.01). Hydrogen sulfide level was higher in patients with normoalbuminuria (66.8±7.2 µmol). There was a moderate positive correlation between systolic blood pressure and microalbuminuria (r=0.3804; p<0.01) and a moderate negative correlation between hydrogen sulfide and microalbuminuria (r=0.3404; p<0.01). Conclusions. We revealed a decrease in hydrogen sulfide level to 57.4±7.9 µmol in patients with metabolic syndrome. This may be an early predictor of kidney damage.

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Ìåòà. Äîñë³äèòè ð³âåíü ã³äðî´åí ñóëüô³äó ïàö³ºíò³â ç öóêðîâèì ä³àáåòîì 2 òèïó çàëåaeíî â³ä íàÿâíîñò³ ä³àáåòè÷-íî¿ íåôðîïàò³¿. Ìàòåð³àë ³ ìåòîäè. Îáñòåaeåíî 70 ïàö³ºíò³â (40 ÷îëî-â³ê³â ³ 30 ae³íîê) ³ç öóêðîâèì ä³àáåòîì 2 òèïó. Îêð³ì ñòàíäàðòíèõ ëàáîðàòîðíèõ ìåòîä³â îáñòåaeåííÿ, äîäàòêîâî áóâ ïðîâåäåíèé çàá³ð êðîâ³ ç âåíè äëÿ âèçíà÷åííÿ ð³âíÿ ã³äðî´åí ñóëüô³äó (äîñë³ä âèêîíóâàëà ñò. ëàá. Ïðóñ ².Â., êàôåäðà á³îëî´³÷íî¿ õ³ì³¿ ËÍÌÓ ³ì. Äàíèëà Ãàëèöüêîãî), à òàêîae çàá³ð äîáîâî¿ ñå÷³ äëÿ âèçíà÷åííÿ ð³âíÿ àëüáóì³-íóð³¿. Óñ³ õâîð³ áóëè ïîä³ëåí³ íà 2 ãðóïè: 1-áåç ä³àáåòè÷íî¿ íåôðîïàò³¿, 2-ç ä³àáåòè÷íîþ íåôðîïàò³ºþ. Õâîð³ îòðèìóâàëè àíòèä³àáåòè÷íå ë³êóâàííÿ ó âèãëÿä³ ìåòôîðì³íó. Äëÿ ñòàòè÷íî¿ îáðîáêè ðåçóëüòàò³â ðîçðàõîâóâàëè ïîêàçíèê êîðåëÿö³¿ ϳðñîíà òà t-êðèòåð³é Ñòüþäåíòà. Ðåçóëüòàòè é îáãîâîðåííÿ. Ó äîñë³äaeåíí³ âèÿâëåíî, ùî ð³âåíü ã³äðî´åí ñóëüô³äó º çíà÷íî çíèaeåíèì ó ïàö³ºíò³â ç ä³àáåòè÷íîþ íåôðîïàò³ºþ òà íå´àòèâíî êîðåëþº ç ³íäèêàòîðàìè ä³àáåòè÷íî¿ íåôðîïàò³¿ -ì³êðîàëüáóì³íîì òà øâèäê³ñòþ êëóáî÷êîâî¿ ô³ëüòðàö³¿. Âèñíîâêè. гâåíü ã³äðî´åí ñóëüô³äó º çíèaeåíèì ó õâîðèõ ç ä³àáåòè÷íîþ íåôðîïàò³ºþ òà ìîaeå áóòè ðàíí³ì ³íäèêàòîðîì ¿¿ âèÿâëåííÿ. Aim. To investigate the level of hydrogen sulfide in patients with type 2 diabetes depending on the presence of diabetic nephropathy. Material and Methods. The investigation included 70 patients with T2D (40 men and 30 women). Besides standard laboratory examination, additional sample of blood for hydrogen sulfide was taken and a 24-hour urine sample for microalbuminuria was collected. All patients were divided in two groups: patients without DN and with DN. Patients underwent antidiabetic treatment with metformin. Independent Student t-test was used to compare the differences between the groups, and Pearson correlation coefficient (r) was calculated. Results and Discussion. It was revealed that hydrogen