The aim of this paper is to describe a schizotypy scale, the Oxford-Liverpool Inventory of Feelings and Experiences (O-LIFE), and its use in psychiatry. Schizotypy is a biologically determined personality phenomenon. Schizotypal disorder, as a diagnostic category in contemporary psychiatric classifications, has been included in schizophrenia spectrum disorders. This may reflect similarities in neurobiological and neuropsychological features between persons with schizotypy and patients with schizophrenia. However, schizotypal traits are also more marked in bipolar disorder (BD) compared with those in healthy subjects. The O-LIFE was created by Claridge and his co-workers and consists of four dimensions: unusual experiences, cognitive disorganisation, introvertive anhedonia and impulsive nonconformity. Studies using O-LIFE in psychiatry, demonstrated a number of associations between the dimensions of the O-LIFE and the clinical features of schizophrenia, in mood disorders and in healthy persons. In patients with BD treated with lithium carbonate, worse effects of lithium were observed in subjects with high scores on the O-LIFE dimensions (particularly cognitive disorganisation). Recently, some molecular-genetic associations have also been shown between O-LIFE dimensions and polymorphisms of the dopaminergic system and circadian rhythm genes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.