The article explores the problem of assessing the scientific and technological progress (STP) parameter in the exogenous economic growth model in the context of modern innovative digital transformation of the economy. The aim of the study is to develop and empirically verify an econometric model for an integrated assessment of the degree of economic agents’ innovative activity influence on the gross regional product. In accordance with the set goal, a methodologically triune (resource-management-resultant) approach to identifying the STP parameter and the corresponding system of economic agents’ innovative activity indicators of the factors are substantiated, an integral-estimated four-module economic mathematical model is proposed and tested. The results of the model testing make it possible to recommend an econometric approach for application in order to analyze and evaluate the scientific and technological progress parameter in innovative spatial economic development trajectories study.