An acute coronary syndrome is a form of clinical manifestation of coronary heart disease with atherosclerosis, and thrombosis processes. Platelets play an essential role in thrombosis. High PDW shows a variation of the morphology, and size of a platelet. This was a retrospective cross-sectional study comparing PDW, length of stay, and patient outcome in STEMI, NSTEMI, UAP, and control patients at the Dr.Wahidin Sudirohusodo Hospital Makassar during the period of January 2014 – December 2015. Data were analyzed using statistical software. One hundred, and seventy-two ACS patients were included; 65 patients had UAP, 48 patients had STEMI and 59 patients had NSTEMI. Sixty normal patients were included as a control. Kruskal-Wallis test showed a statistical difference in PDW between patients with STEMI, NSTEMI, UAP, and control (p=0.000). Post hoc test showed a significant difference between ACS, and control, STEMI, and control (p=0.000), NSTEMI and control (p=0.000), UAP, and control (p=0.000), but there no significant difference     between STEMI, and NSTEMI (p=0.320), STEMI, and UAP (p=0.980), NSTEMI and UAP (p=0.435). There was no significant difference in PDW between patients who survived, and died (p=0.298), and also patients with a length of stay of ≤ 7 days, and > 7 days (p=0.293). Platelet distribution width was higher in ACS patients compared with control patients, but could not be used to predict the outcome, and length of stay of patients with ACS. It is advisable to do further research with a large sample size to avoid bias.

Background: Heart disease is one of the highest mortality diseases and 30% is caused by acute myocardial infarction (AMI). Kidney disease is one of the complications that occurred in patients with acute myocardial infarction.  Several previous studies have reported a high incidence of Acute Kidney Injury (AKI) in patients with AMI (10-27%); the incidence is more elevated when accompanied by cardiogenic shock (50%). Serum BUN and creatinine tests are used to monitor the course and prognosis of renal disorder. This study aims to analyze the BUN/creatinine ratio in IMA patients.Methods: A retrospective cohort study by taking secondary data from medical records in 80 AMI patients (STEMI and NSTEMI) at Dr. Wahidin Sudirohusodo Hospital, Makassar, for January 2017-December 2018. The variables assessed in this study were age, gender, diagnosis, history of the disease, BUN, creatinine, and BUN/creatinine ratio. Data were analyzed using SPSS version 17 for Windows.Results: There was a significant difference between the first examination of ureum (p<0.001), creatinine (p=0.047), and the ratio of BUN/creatinine (p<0.001) with the second examination during treatment in IMA patients, which was higher at the second examination, but there was no association between BUN/creatinine ratio of IMA patients at the first examination with the incidence of renal disorder during treatment (p=0.757).Conclusion: A significant increase of urea and creatinine levels, as well as BUN/creatinine ratio, was found in AMI patients treated at Dr. Wahidin Sudirohusodo Hospital, Makassar. However, no association was found between an increase in the BUN/creatinine ratio and the patient's renal impairment.  Latar Belakang: Penyakit jantung merupakan salah satu penyebab kematian tertinggi dan sebanyak 30% disebabkan oleh infark miokard akut (IMA). Penyakit ginjal merupakan salah satu komplikasi yang dapat terjadi pada pasien infark miokard akut. Beberapa penelitian sebelumnya telah melaporkan tingginya insiden AKI pada pasien IMA (10-27%), insidennya semakin tinggi bila disertai syok kardiogenik (50%). Tes serial BUN dan Kreatinin serum digunakan untuk memantau perjalanan dan prognosis penyakit ginjal. Penelitian ini bertujuan untuk menganalisis hubungan rasio BUN/kreatinin pada pasien IMA.Metode: Penelitian ini bersifat kohort retrospektif dengan mengambil data sekunder dari rekam medis pada 80 pasien IMA (STEMI dan NSTEMI) yang dirawat di RSUP DR. Wahidin Sudirohusodo, Makassar periode Januari 2017-Desember 2018. Variabel yang dinilai pada penelitian ini meliputi usia, jenis kelamin, BUN, kreatinin, maupun rasio BUN/kreatinin serum. Data dianalisis dengan piranti lunak SPSS versi 17 untuk Windows. Hasil: Penelitian ini menunjukkan terdapat perbedaan bermakna pemeriksaan pertama ureum (p<0,001), kreatinin (p=0,047), dan rasio BUN/kreatinin (p<0,001) dengan pemeriksaan kedua selama perawatan pada pasien IMA, yaitu lebih tinggi pada pemeriksaan kedua, akan tetapi tidak terdapat hubungan rasio BUN/kreatinin pasien IMA pada pemeriksaan pertama dengan kejadian gangguan fungsi ginjal selama perawatan (p=0,757).Simpulan: Berdasarkan hasil penelitian, ditemukan peningkatan yang signifikan dari kadar ureum, kreatinin, dan rasio BUN/kreatinin pasien IMA yang dirawat di RSUP Dr. Wahidin Sudirohusodo, Makassar. Akan tetapi, rasio BUN/kreatinin tidak dapat dijadikan sebagai prediktor terhadap gangguan fungsi ginjal pasien IMA.