As several COVID-19 vaccine candidates approach approval for human use, governments around the world are preparing comprehensive standards for vaccine distribution and monitoring to avoid long-term consequences that may result from rush-to-market. In this early draft article, we identify challenges for vaccine distribution in four core areas -logistics, health outcomes, user-centric impact, and communication. Each of these challenges is analyzed against five critical consequences impacting disease-spread, individual behaviour, society, the economy, and data privacy. Disparities in equitable distribution, vaccine efficacy, duration of immunity, multi-dose adherence, and privacy-focused record keeping are among the most critical difficulties that must be addressed. While many of these challenges have been previously identified and planned for, some have not been acknowledged from a comprehensive view to account for unprecedented repercussions in specific subsets of the population.The logistics of equitable, widespread vaccine distribution in disparate populations and countries of various economic, racial, and cultural constitutions requires careful planning and consideration for global vaccine success. We also describe unique challenges regarding vaccine efficacy in specialized populations including children, the elderly, and immunocompromised individuals [1,27]. Furthermore, we report the potential for understudied drug-vaccine interactions as well as the possibility that certain vaccine platforms may increase susceptibility to HIV infection [77,14]. Given these complicated issues, the importance of privacy-focused, user-centric systems for vaccine education and incentivization along with clear communication from governments, organizations, and academic institutions is imperative. These challenges are by no means insurmountable, but require thorough consideration to avoid consequences that span a range of disease-related, individual, societal, economic, and security domains.
