A double-blind, randomized, phase II clinical trial was conducted within a 14-week follow-up including 2 weeks of the non-drug run-in period, 8 weeks of medication, and 4 weeks of follow-up after discontinuation. The objective of the study was to evaluate the efficacy and safety of Trang Phuc Linh Plus in irritable diarrhea syndrome patients. Group I took Trang Phuc Linh Plus 3 tablets/time x 2 times/day for 8 weeks; Group II took placebo 3 tablets/time x 2 times/day for 8 weeks. Patients will be re-examined, tested, and evaluated over the phone for symptom recurrence and adverse events (AEs). This study showed that the Trang Phuc Linh Plus tablets tended to improve symptoms in patients suffering from irritable bowel syndrome with diarrhea, suggesting its safety and tolerability.

“Dong trung ha thao Sapa” (DTHT) capsules, prepared from Cordyceps militaris powder, are intended to be used in relieving menopausal signs and symptoms. The current study aimed to evaluate the estrogenic properties of DTHT capsules on experimental animals. Female mice from 6 to 8 weeks were used for the study. Mice were divided into the following groups: group I - normal control without being ovariectomized (saline-treated); group II to V were ovariectomized, group II (saline-treated); group III (Ethinyl estradiol-treated), group IV (low dose DTHT capsules) and group V (high dose DTHT capsules). The potential effect of DTHT capsules was evaluated by measuring both the wet and blotted uterus weights. The uterus was then fixed in 10% neutral buffered formalin, HE(Haematoxylin & Eosin) stained and examined histopathologically. The results suggest that DTHT capsules show estrogenic activity in ovariectomized mice by increasing wet uterus and blotted uterus weight and improving the uterus’s histology. DTHT capsules appear to be an effective therapeutic drug for the treatment of menopausal symptoms.

Phong thap dan tablets are intended to treat low back pain. This study was carried out to evaluate theanalgesic effects of Phong thap dan tablets in experimental animals. The analgesic effects were evaluated inthree animal models: hot plate, mechanical stimulation and acetic acid-induced writhing test. Mice were dividedinto 4 groups given oral water, control drug (codein phosphate in hot plate and mechanical stimulation tests oraspirin in writhing test), Phong thap dan at 2.88 tablets (1.44 g) or 8.64 tablets (4.32 g)/kg b.w/day, respectively.Our results showed that Phong thap dan tablets at both doses increased the reaction time to thermal stimulation,increased the paw withdrawal latency and the force required to elicit a paw withdrawal and decreased thenumber of acetic acid-induced writhing movements in mice. There was no statistically significant differencebetween 2 doses of Phong thap dan tablets in three animal models. We conclude that Phong thap dan tabletsat the doses of 2.88 tablets and 8.64 tablets/kg b.w/day showed significant analgesic effect in animal models.

The study aimed to evaluate the acute and subchronic toxicities of “Phuong Dong Dai Trang” tablets through oral administration using experimental animal models. Acute toxicity in Swiss mice was determined using the Litchfield Wilcoxon method. The subchronic toxicity in Wistar rats was evaluated according to WHO and OECD’s recommendation with oral doses of 4.68 g/kg/day (equivalent to recommended human dose) and 14.04 g/kg/day (3 times the recommended human dose) for 4 consecutive weeks. In terms of acute toxicity, “Phuong Dong Dai Trang” tablets did not express acute toxicity in mice at the highest dose used (232.14 g materials/kg). In terms of the subchronic toxicity, after oral administration of “Phuong Dong Dai Trang” tablets, hematological parameters, hepato - renal functions, and microscopic images of liver and kidney were unchanged in the treatment group compared to the control group. In conclusion, “Phuong Dong Dai Trang” tablets did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.