Salinity has become one of the most important challenges in agriculture. A pot experiment was conducted during 2017/2018 and 2018/2019 seasons at the greenhouse of Fac. Agric., Cairo Univ., Giza, Egypt, on Triticum aestivum L., var. Gemmiza 10. Plants irrigated with diluted seawater with tap water (control), 4.0 6.0, 8.0 and 10.0 dS m-1 to investigate the utilization of co-inoculation of plant growth promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF) and the addition of compost individually or in combination as an environmentally sustainable tools to alleviate the effects of salinity on wheat plants at both 75 days after sowing (DAS) (elongation stage) and 150 DAS (maturity stage). Salinity stress caused significant reduction in shoot height, shoot fresh and dry weights, K+/Na+ ratio and nitrogen, phosphorous and potassium contents of shoot at 75 DAS, however, Na+ concentration increased significantly. At maturity yield and its attributes, nitrogen, phosphorous and potassium contents in grain and straw decreased significantly with increasing irrigation water salinity level. Co-inoculation and/or compost amendments increased significantly the growth parameters and yield components compared to untreated plants under all irrigation water salinity levels.