No abstract

The observation that survival was significantly better in the groups of patients who received tumor-negative harvests and worse for patients who received minimally contaminated harvests suggests that tumor cells, even at minimal levels, reinfused in the transplanted harvest are responsible for progression in a proportion of patients who achieve a CR following HDT, although other biologic characteristics of the tumor could also be important. A relatively good outcome can be achieved with HDT and PSCT, even in patients with a significant marrow tumor burden.

No abstract

Peripheral stem cell (PSC) harvests from patients with non-Hodgkin's lymphoma (NHL) and breast cancer are less likely t o be contaminated with occult tumor cells detected by culture techniques, than are bone marrow harvests.Clinically, NHL patients transplanted with such PSC harvests had a better outcome than recipients of bone marrow harvests.

C urrently recommended N management in North Carolina and elsewhere in the humid southeastern USA is based on realistic yield expectations (RYE). In North Carolina, N recommendations based on RYE are made from a database of RYE by soil map unit or based on a grower's documented historic yields (the average of the best three yields during a 5-yr period; North Carolina Nutrient Management Workgroup, 2003). The recommended N rate is calculated using the RYE and a soil-and crop-dependent N application factor (18-22.5 kg N Mg −1 corn grain yield). These N fertilizer recommendations are based on decades of fi eld response trials (Kamprath et al., 1973; Kamprath, 1986), but can result in under-or overapplication, in part because they do not consider soil N (Mulvaney et al., 2001). Soils under certain management practices (e.g., manure applications or legume cover crops) or soils with high organic matter content may have suffi cient residual and potentially mineralizable N for optimum corn growth and need little or no N fertilizer. Overapplication of N fertilizer has been linked to high levels of NO 3 in shallow groundwater underneath agricultural fi elds in North Carolina and elsewhere (Gambrell et al., 1974; Jacobs and Gilliam, 1985). The Neuse River Basin in North Carolina has experienced fi sh kills linked to nonpoint sources of NO 3 pollution (North Carolina Division of Water Quality, 1996, p. 44). Agricultural N pollution could be reduced by more effectively determining accurate fertilizer rates, so less N is susceptible to leaching and runoff (Khan et al., 2001). A soil N test to predict corn N need or corn responsiveness to N fertilizer could be used to more accurately predict fertilizer recommendations. The challenge is to develop a soil N test that is accurate, timely, and cost effective for predicting corn yield response to N fertilizer or corn fertilizer N requirement. The climate in the southeastern USA complicates soil N test development because of warm temperatures and rainfall that exceeds evapotranspiration, resulting in rapid mineralization, immobilization, leaching, and denitrifi cation. The preplant and presidedress NO 3 tests have had limited success in estimating corn N need in the humid southern USA (Bundy et al., 1992; Grove, 1992). Soil N tests that measure mineralizable N under aerobic conditions are not practical for predicting yield response to fertilizer because they require a long incubation period (30-60 d; Bundy and Meisinger, 1994). Potential soil tests for predicting fertilizer response in corn would be an anaerobic IRNT (Bundy