Traditional project planning tools and methodologies fail to address the dynamic uncertainties that can arise during project execution. In this article, we develop an approach to enable project managers to design project networks capable of performing predictably under uncertainty. We integrate a validated project organization design simulation tool (Virtual Design Team) with a robust design experimental method to enable robust project network design. We test the framework on a 13-month, U.S. $11.5M public renovation project. We find that: (1) it is possible to integrate the project organization design tool with the robust design experimental method for the test case project; (2) the integrated approach enables project managers to identify and simulate the combination of interventions that will lead to the most robust project performance; and (3) the integrated approach can extend the capabilities of project managers to design project networks in dynamically uncertain project environments. The findings highlight the need to explore new ways to achieve predictable project performance in dynamically uncertain project execution environments.