Variation of the copper-catalyzed Huisgen 1,3dipolar cycloaddition inVolVing a one-pot two-step transformation of trimethylsilyl-protected alkyne reactants was used to prepare multidentate N-heterocyclic chelators containing 1,2,3triazole rings in high yields. This includes the first reported examples of 1,1′-disubstituted 4,4′-bis(triazole) bidentate chelators deriVed from click preparations.The N-heterocyclic chelators 2,2′-bipyridine (bpy) and 2,2′: 6′,2′′-terpyridine (tpy) have been widely studied, due to their predictable coordination environments and the interesting optoelectronic properties that can result from ligand-metal interactions. Such qualities can be exploited for supramolecular assembly, molecular electronics, and catalysis applications, 1 each often requiring the peripheral incorporation of synthetic handles for physical property manipulation or incorporation into functional systems. Because functionalization of polypyridine-based chelators can be synthetically demanding, 2 it remains important to seek new approaches in the preparation of analogous multidentate chelating motifs that also possess well-defined coordination properties and can be prepared and modified with high efficiency.

Objective This study aimed to determine the factors associated with positive infant drug screen and create a shortened screen and a prediction model. Study Design This is a retrospective cohort study of all infants who were tested for drugs of abuse from May 2012 through May 2014. The primary outcome was positive infant urine or meconium drug test. Multivariable logistic regression was used to identify independent risk factors. A combined screen was created, and test characteristics were analyzed. Results Among the 3,861 live births, a total of 804 infants underwent drug tests. Variables associated with having a positive infant test were (1) positive maternal urine test, (2) substance use during pregnancy, (3) ≤ one prenatal visit, and (4) remote substance abuse; each p-value was less than 0.0001. A model with an indicator for having at least one of these four predictors had a sensitivity of 94% and a specificity of 69%. Application of this screen to our population would have decreased drug testing by 57%. No infants had a positive urine drug test when their mother's urine drug test was negative. Conclusion This simplified screen can guide clinical decision making for determining which infants should undergo drug testing. Infant urine drug tests may not be needed when a maternal drug test result is negative. Key Points