Plasmonic nanoparticles (NPs) are one of the most promising and studied inorganic nanomaterials for different biomedical applications. Plasmonic NPs provide excellent biocompatibility, long-term stability against physical and chemical degradation, relevant optical properties, well-known synthesis methods and tuneable surface functionalities.Herein, a review of recently reported bioconjugated plasmonic NPs using different chemical approaches and loading cargoes (such as drug, gene, and proteins) for enhancement of transdermal delivery across biological tissues is presented. The main aim is the understanding of the interaction of the complex skin structure with biomimetic plasmonic NPs. This knowledge not only plays an important role for enhancing transdermal delivery of pharmaceutical formulations but also for controlling undesired skin penetration of industrial products, such as cosmetic, sunscreen formulations and any other mass-usage consumable containing nanoparticles.