In this report, the first steps of the synthesis of a novel surfactant have been described. Each stage has been optimized to abide by the principles of green chemistry. The replacement of CMR (Carcinogenic, Mutagenic, Reprotoxic) solvents by 4‐MTHP (4‐methyltetrahydropyran) led to the improvement of the overall yield and to the drastic reduction of the total organic solvent volume used in the process.

This article describes the synthesis of a new bio-based organocatalytic surfactant. The nine steps of the synthesis were optimized, fully respecting the principles of green chemistry. The surfactant aspect was then evaluated with the use of tensiometric studies. The molecular organization of the surfactant in vesicles in an aqueous medium was characterized by Dynamic Light Scattering (DLS) and confirmed using Density Functional Theory (DFT) modelling.