When citrate ligands-capped gold nanoparticles are mixed with blood sera, a protein corona is formed on the nanoparticle surface due to the adsorption of various proteins in the blood to the nanoparticles. Using a two-step gold nanoparticle-enabled dynamic light scattering assay, we discovered that the amount of human immunoglobulin G (IgG) in the gold nanoparticle protein corona is increased in prostate cancer patients compared to noncancer controls. Two pilot studies conducted on blood serum samples collected at Florida Hospital and obtained from Prostate Cancer Biorespository Network (PCBN) revealed that the test has a 90-95% specificity and 50% sensitivity in detecting early stage prostate cancer, representing a significant improvement over the current PSA test. The increased amount of human IgG found in the protein corona is believed to be associated with the autoantibodies produced in cancer patients as part of the immunodefense against tumor. Proteomic analysis of the nanoparticle protein corona revealed molecular profile differences between cancer and noncancer serum samples. Autoantibodies and natural antibodies produced in cancer patients in response to tumorigenesis have been found and detected in the blood of many cancer types. The test may be applicable for early detection and risk assessment of a broad spectrum of cancer. This new blood test is simple, low cost, requires only a few drops of blood sample, and the results are obtained within minutes. The test is well suited for screening purpose. More extensive studies are being conducted to further evaluate and validate the clinical potential of the new test.

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In carbonate terranes, rocks types that provide apatite are not available to effectively use apatite fission track (AFT) or (U/Th)‐He chronometry (AHe). Here we suggest that calcite cave spar can be an effective chronometer and complimentary to AFT and AHe thermochronometers in carbonate regions such as our study area, the Guadalupe Mountains of southeastern New Mexico, and west Texas. Our measured depth of cave spar deposition is 500 ± 250 m beneath the regional water table, formed at temperatures of 40° to 80°C, indicating that these caves and their spar crystals form near the supercritical CO2‐subcritical CO2 boundary where we interpret the origin of both the caves and spar to occur. This depth‐temperature relationship suggests a higher than normal geotherm, likely associated with regional magmatic activity. As a case study we examined the timing of uplift of the Guadalupe Mountains previously attributed to the compressional Laramide orogeny (ca. 90 to 50 Ma), later extensional tectonics associated with Basin and Range (ca. 36 to 28 Ma) or the opening of the Rio Grande Rift (ca. 20 Ma to Present). We show that most of the spar origin is coeval with the ignimbrite flare‐up between 36 and 28 Ma. Our results constrain the initiation of Guadalupe Mountains block uplift, relative to the surrounding terrain, to between 27 and 16 Ma and reconstruct the evolution of a low‐lying regional landscape prior to block uplift from 185 to 28 Ma, in support of models that attribute regional surface uplift to extensional tectonics and associated volcanism.