We study interactions of cosmological relics, X, of mass m and electric charge qe in the galaxy, including thermalization with the interstellar medium, diffusion through inhomogeneous magnetic fields and Fermi acceleration by supernova shock waves. We find that for m < ∼ 10 10 q GeV, there is a large flux of accelerated X in the disk today, with a momentum distribution ∝ 1/p 2.5 extending to (βp) max ∼ 5 × 10 4 q GeV. Even though acceleration in supernova shocks is efficient, ejecting X from the galaxy, X are continually replenished by diffusion into the disk from the halo or confinement region. For m > ∼ 10 10 q GeV, X cannot be accelerated above the escape velocity within the lifetime of the shock. The accelerated X form a component of cosmic rays that can easily reach underground detectors, as well as deposit energies above thresholds, enhancing signals in various experiments. We find that nuclear/electron recoil experiments place very stringent bounds on X at low q; for example, X as dark matter is excluded for q > 10 −9 and m < 10 5 GeV. For larger q or m, stringent bounds on the fraction of dark matter that can be X are set by Cherenkov and ionization detectors. Nevertheless, very small q is highly motivated by the kinetic mixing portal, and we identify regions of (m, q) that can be probed by future experiments.

Dynamic regulation of cerebral tissue oxygenation is associated with neurocognitive dysfunction in aMCI patients.

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