One of the challenges for iterative image reconstruction (IIR) is that such algorithms solve an imaging model implicitly, requiring a complete representation of the scanned subject within the viewing domain of the scanner. This requirement can place a prohibitively high computational burden for IIR applied to x-ray computed tomography (CT), especially when high-resolution tomographic volumes are required. In this work, we aim to develop an IIR algorithm for direct region-of-interest (ROI) image reconstruction. The proposed class of IIR algorithms is based on an optimization problem that incorporates a data fidelity term, which compares a derivative of the estimated data with the available projection data. In order to characterize this optimization problem, we apply it to computer-simulated two-dimensional fan-beam CT data, using both ideal noiseless data and realistic data containing a level of noise comparable to that of the breast CT application. The proposed method is demonstrated for both complete field-of-view and ROI imaging. To demonstrate the potential utility of the proposed ROI imaging method, it is applied to actual CT scanner data.

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This paper proves continuity of value functions in discounted periodic-review single-commodity total-cost inventory control problems with fixed ordering costs, possibly bounded inventory storage capacity, and possibly bounded order sizes for finite and infinite horizons. In each of these constrained models, the finite and infinite-horizon value functions are continuous, there exist deterministic Markov optimal finite-horizon policies, and there exist stationary deterministic Markov optimal infinite-horizon policies. For models with bounded inventory storage and unbounded order sizes, this paper also characterizes the conditions under which (s t , S t ) policies are optimal in the finite horizon and an (s, S) policy is optimal in the infinite horizon.