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A new species of medium-sized and upright-flowered Kalanchoe Adans. (Crassulaceae) from medium altitude moist evergreen forests in northern Madagascar is described and illustrated: K. apiifolia D.-P. Klein, Shtein & Callm. By its herbaceous habit, forming erect flowers with a short and indistinct calyx tube, ligulate nectary scales, and not possessing bulbils of any kind, it represents a member of Kalanchoe subg. Kalanchoe. Morphologically, K. apiifolia is most similar to K. briquetii Raym.-Hamet but differs from it by being glabrous throughout, by having bi-to tripinnate leaves that are particularly long petiolate, and by the seed-bearing part of the carpels being about as long as the stylar part. The new species is preliminary assessed as "Endangered" [EN] using the IUCN Red List Categories and Criteria.