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Background. Allium species extracts including Allium cepa L. contain sulfur compounds, known for their antiplatelet, antimicrobial, antineoplasic activities. Methodology. Antibacterial activity of a formulation based on A. cepa extracts-liquid and lyophilized samples, has been demonstrated using two classes of bacteria: Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) and three methods: discs soaked with liquid extract, the wells method in the culture medium, filled with the liquid extract and lyophilized formulation extracts transformed by the incorporation of ultrapure water. The second part of this study includes identification of thiosulfinates compounds from the studied samples by high performace liquid chromatography-mass spectrometry (HPLC-MS). Results. The most important inhibition and the highest antibacterial efficiency were observed against Gram-positive bacteria, such as Staphylococcus aureus. The HPLC-MS † These authors equally contributed to this paper.

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