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A trial of the killed Coccidioides immitis spherule vaccine was undertaken with 151 healthy skin test negative adult volunteers and controls to evaluate the safety of selected regimens, the induction of humoral and cell-mediated immune responses, and to determine if there were immunogenetic differences in these responses. The vaccine was given as three intra-deltoid doses over 8 weeks. No severe systemic symptoms were noted, although 3% of 3.5 mg doses (but no 1.75 mg doses) were associated with severe local reactions. Half the vaccinees had skin test conversions, which generally persisted greater than or equal to 6 months, two-thirds showed boosting of lymphocyte transformation in vitro, and 16% given three 3.5 mg doses developed antibody. There was an association between degree of local adverse vaccine reaction and immunostimulation, and a trend to immune response in persons of O blood type and with some HLA phenotypes. There was no evidence of deficient response to vaccination in subpopulations known to respond to coccidioidal infection poorly. A regimen of three 1.75 mg doses appears to be safe and without reduced immunogenicity, and there is no evidence dosage modification for certain subpopulations would be necessary in efficacy studies.

In the midst of a severe winter storm, SUMMIT IVF celebrated its inaugural meeting in Aspen, Colorado, on February 6-8, 2020. This invitation-only thought retreat gathered >50 clinicians, administrators, investors, and researchers from across the world to discuss the future of assisted reproduction, understand existing challenges, and explore opportunities for the future. The meeting was organized by the Fertility Collective, a group of fertility focused companies dedicated to establishing best practices in reproductive medicine.The summit was intentionally small to foster community, and no sponsor funding was accepted. The intimate size of the meeting allowed for ample group and individual discussions and created an exciting environment where attendees could engage on a broad range of topics openly.

This chapter deals with an online course using innovative pedagogy and innovative technology to enable transformative learning. It concerns the application of reflective practices including mindfulness, guided contemplation, and journal writing as the groundwork for active listening, inquiry, and dialogue that builds new meaning for individuals and groups. Positive student feedback and preliminary research indicate individual and interactive contemplation exercises strengthen characteristics of transformative learning.