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Background: Thyroid dysfunction is a public health problem in White Nile State in Sudan. It is majorly caused by iodine deficiency. Hyperprolactinemia, the clinical condition associated with infertilityis resulted from a number of causes. Objectives: This study aimed to assess the relationship between thyroid hormone and prolactin serum level in Sudanese hypothyroidism infertile females. Material and Method: One hundred Sudanese females with hypothyroidism were compared with eightys healthy control. Blood samples were collected after an overnight fasting. Serum TSH, T3, T4 were analyzed using fully automated immunoassay analyzer system (AIA)TOSOH BIOSCINCEAIA360. Prolactin is measured using i-CHROMATM. Results: Hypothyroidism patients showed increased prolactin levels. Prolactin is increased in 40% of hypothyroidism patients.Also, TSH levels were significantly positively correlated with prolactin levels. Conclusion:The serum prolactin levels were increased in hypothyroidism infertile patients.

The southern part of Saudi Arabia has an ethnically diverse population where sickle-cell anemia (sickle cell disease) is common, but little is known about its βs haplotypes. The goal of the current study is to ascertain the prevalence of the Hb S gene with analysis of Xmn1 ′5 to Gγ haplotype among the Saudi population in the Jazan area. Initially recorded findings of (1) Hb S gene and (2) hematological parameters with Hb F levels were collected from 5990 participants. Then, the second series of 70 different patients with established sickling disease and 30 healthy individuals as a control group was recruited, in which the genotype of Xmn1 ′5 to Gγ-SNP was performed by PCR-RFLP. In the first series, the prevalence of Hb types was AA at 86.8% (N = 5198), AS at 12.4% (N = 745), and SS at 0.8% (N = 47). Of the second series, three patients (4.3%) were (±) Xmn1 ′5 to Gγ and 67 (95.7%) were (−/−) in Xmn1 ′5 to Gγ. In the controls, the (±) Xmn1 ′5 to Gγ was observed in only one individual (3.3%), aged 30. These findings possibly represent a new Saudi haplotype, [±] Xmn1 ′5 to Gγ. Our results demonstrate that most patients with SCD in Jazan have [−/−] Xmn1 with higher levels of Hb F and positive Xmn1 ′5 to Gγ normally associated with a low level of Hb F.