Introduction: Polycystic ovary syndrome (PCOS) is one of the major causes of infertility Worldwide and affects about 20% of infertile couples. Patients with PCOS have an increased risk of first trimester spontaneous abortion ranging from 25% to 73%. Repeated pregnancy loss (RPL), specified as two or more consecutive pregnancy losses before the 20th week of pregnancy is a frequent obstetric complication. In spite of this, 50% of cases the pathophysiology remains unknown Aim of the work: The purpose of this work was to prevent early recurrent pregnancy loss in adult females with polycystic ovary syndrome and hyperhomocysteinemia by using folic acid 5mg/daily. Methods: The current study was carried out on 80 pregnant women in reproductive period, their age ranged from 20 to 35 ages. They were assorted into two groups: group one studying 40 women having a history of RPL with PCOS and group two including 40 adult females having a history of RPL and non PCOS. The women in the two groups were treated with 5mg/day folic acid/day for 20 weeks. Results: Homocysteine level in patients with RPL and polycystic ovary was significantly higher than in women without polycystic ovary syndrome. In addition, folic acid administration at a daily dosage of 5 mg reduced significantly the rate of fetal loss. Conclusion: We found that folic acid supplementation early in pregnancy, in a pharmacological dose might have a beneficial effect on pregnancy outcome.