In the setting of a challenge competition, some deep learning algorithms achieved better diagnostic performance than a panel of 11 pathologists participating in a simulation exercise designed to mimic routine pathology workflow; algorithm performance was comparable with an expert pathologist interpreting whole-slide images without time constraints. Whether this approach has clinical utility will require evaluation in a clinical setting.

Learning effective feature representations and similarity measures are crucial to the retrieval performance of a content-based image retrieval (CBIR) system. Despite extensive research efforts for decades, it remains one of the most challenging open problems that considerably hinders the successes of real-world CBIR systems. The key challenge has been attributed to the well-known "semantic gap" issue that exists between low-level image pixels captured by machines and high-level semantic concepts perceived by human. Among various techniques, machine learning has been actively investigated as a possible direction to bridge the semantic gap in the long term. Inspired by recent successes of deep learning techniques for computer vision and other applications, in this paper, we attempt to address an open problem: if deep learning is a hope for bridging the semantic gap in CBIR and how much improvements in CBIR tasks can be achieved by exploring the state-of-the-art deep learning techniques for learning feature representations and similarity measures. Specifically, we investigate a framework of deep learning with application to CBIR tasks with an extensive set of empirical studies by examining a state-of-the-art deep learning method (Convolutional Neural Networks) for CBIR tasks under varied settings. From our empirical studies, we find some encouraging results and summarize some important insights for future research.