The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

The levels of erythropoietiti and metabolic s t i n~u l a t i~~g factor\s) were assayed in the plasma of (logs a t I and 3 hours and a t 2, 3, 4, 6-7, and 8-0 days after the rapid production of anaemia by dextral-for-blood exchange. The assay results were considered in relation to the reticulocyte response and oxygen c.onsurnption of the anaemic dogs over this same period.An increase in erythropoietiii was ilrst detected a t 2 days and reached a maximum by 4 days after exchange. The level of erythro~~oietin was falling by 6-7 days and reached control levels by 8-0 days. A I~ increase in reticulocyte level in anaemic dogs did not occur until 3-4 days and was maximal a t 8-9 days. The ~netabolic stimulating activity of the plasmla t ended to parallel the changes in level of erythropoietin except a t 3 hours when there was a considerable incre,rse in metabolic activity although there was a rlormal level of erythropoietin. Proteinbound iodine in plasma was decreased followi~lg dextran-for-lAood exchange. The oxygen consumption of the anaemic dog was below control levels at I and :( hours, but subsequently above control levels at 4 to $1 days.The changes in erythropoietiil and ~lletabolir sti~nulatiilg factor were somewhat sinlilar to the change in level of a cardiot~nic agent previo~~sly fvrind in t h e blood of dogs during recovery from anaemia.

No abstract