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A diastereoselective synthesis of the β-anomer of glycinamide ribonucleotide (β-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic β-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

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The decision to come to the USA for pursuing my doctoral studies was not an easy one. Looking back I feel very glad that I made that decision because it has not just helped me earn my degree, everything about living on my own has been a learning experience. As I prepare to start a new chapter in life, I would like to thank my advisor Prof. George O'Doherty and Northeastern University for giving me the opportunity to pursue my Ph.D. at the Department of Chemistry. I cannot thank George enough for his mentorship, guidance and support. His influence will undoubtedly be the strongest influence on me for years to come. I would also like to sincerely thank my committee members Prof. Penny J. Beuning, Prof. Roman Manestch and Prof. Ganesh Thakur for their guidance and support. I would like to thank the entire faculty and staff at Northeastern University for their guidance and help. I would like to thank Prof. Penny J. Beuning and Prof. Mary Jo Ondrechen for entrusting me with collaborative projects. I am very thankful for the mentorship of my group members, Dr. Ehesan U. Sherif and Dr. Sumit O. Bajaj during the early years. Fellow researcher Lisa Ngu at Prof. Beuning's Lab deserves special acknowledgement for bringing the collaborative projects to reality. I would like to thank all of my former and present group members Dr.