No abstract

No abstract

No abstract

Since the dawn of mankind, science and faith have always been given as antonyms and have fought for popular recognition. However, these days the association between these areas is discussed for a better result, since believing in one of these aspects does not mean disregarding the importance of the other, even in terminal patients. The objective was to analyze the experience of spirituality/religion in supporting cancer patients and to discuss the lack of preparation and use of these tools by health professionals. The literature review was based on the BVS Brazil (Virtual Health Library), Google Scholar and PubMed databases from 2017 to 2020. The keywords used were “spirituality”, “religion”, “neoplasms” and "health". As an inclusion criterion, free full texts in English were used. The scientific search initially showed 86 articles where after the evaluation of their titles and respective abstracts, duplicates and those that were incompatible with the scope of the study were excluded, totaling 31 articles. After attaching an article separately, 31 articles were fully read for the construction of this work. Concluding that spirituality and religion are important in the lives of terminally ill patients who seek tools to cope with the disease and to continue treatment, showing the importance of these in the way of dealing with the patient, thus improving the prognosis.

Introduction: Refractory epilepsy (RE) is a disease that causes continuous and debilitating seizures. Due to the ineffectiveness of antiepileptic therapies, there is a growing interest in drugs made with cannabidiol (CBD), a substance extracted from Cannabis. Objective: To point out benefits and challenges of the use of CBD in the treatment of RE. Methods: Literature review performed at PubMed, with the descriptors Epilepsy, Drug Therapy and Cannabis. Results: It is suggested that CBD is mediated by cannabinoid receptors coupled to protein G, by blockade of NMDA receptors, by GABAergic modulation, glutamatergic synapses and / or mechanisms involving noncannabinoid receptors. CBD can also oppose the actions of exogenous and endogenous cannabinoid agonists, due to the negative allosteric modulation. The benefits of CBD are: great therapeutic diversity, safety and tolerability, rare and mild side effects, low risk of drug interactions, and milder cognitive effects, when compared to other antiepileptic drugs. Despite the benefits, CBD has adverse effects such as drowsiness, appetite reduction, diarrhea, increased activity of liver enzymes and interaction with substances metabolized by cytochrome P450. Still, the inefficient regulation generates variation in the composition of the marketed drugs, which can lead to Δ9 - tetrahydrocannabinol (THC) intoxication. Conclusions: Thus, it is essential that the scientific community remains open to investigate the effects of CBD, given the advantages of its use for treating RE.