Horseradish peroxidase-mediated polymerization of styrene at ambient temperature is reported. Molecular weight and yield of polystyrene were influenced by solvent, concentration of hydrogen peroxide, and initiator (beta-diketones, coumarin). THF:H2O (v/v) and hydrogen peroxide (0.082 mol/L) provided maximum yield of polymer (21.2% weight conversion of styrene to polystyrene) with 2,4-pentanedione as initiator. 1,3-Cyclopentanedione and dibenzoylmethane as initiators resulted in higher yield of polymer (approximately 60%) and a higher molecular weight (Mn = 96,504, polydispersity = 2.16), respectively. This enzymatic strategy was also used for the synthesis of polymers from styrene derivatives, 4-methylstyrene and 2-vinylnaphthalene, the latter resulting in a > 90% yield of polymer. The presence of the initiators in the polymer chains is reported.

Low-energy eigenmode excitations of ferromagnets are spin waves or magnons that can be triggered and guided in magnonic circuits without Ohmic losses and hence are attractive for communicating and processing information. Here we present new types of spin waves that carry a definite and electrically controllable orbital angular momentum (OAM) constituting twisted magnon beams. We show how twisted beams emerge in magnonic waveguides and how to topologically quantify and steer them. A key finding is that the topological charge associated with OAM of a particular beam is tunable externally and protected against magnetic damping. Coupling to an applied electric field via the Aharanov-Casher effect allows for varying the topological charge. This renders possible OAM-based robust, low-energy consuming multiplex magnonic computing, analogously to using photonic OAM in optical communications, and high OAM-based entanglement studies, but here at shorter wavelengths, lower energy consumption, and ready integration in magnonic circuits.

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The objective of this study was to develop hydroxypropyl methylcellulose (HPMC) based controlled release (CR) formulations via hot melt extrusion (HME) with a highly soluble crystalline active pharmaceutical ingredient (API) embedded In the polymer phase. HPMC is considered a challenging CR polymer for extrusion due to its high glass transition temperature (Tg), low degradation temperature, and high viscosity. These problems were partially overcome by plasticizing the HPMC with up to 40% propylene glycol (PG). Theophylline was selected as the model API. By using differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), dynamic mechanical analysis (DMA), and X-ray powder diffraction (XRPD), the physical properties of the formulations were systematically characterized. Five grades of HPMC (Methocel(®)) - E6, K100LV, K4M, K15M, and K100M - were tested. The extrusion trials were conducted on a 16 mm twIn screw extruder with HPMC/PG placebo and formulations containing theophylline/HPMC/PG (30:42:28, w/w/w). The dissolution results showed sustained release profiles without burst release for the HPMC K4M, K15M, and K100M formulations. The extrudates have good dissolution stability after being stressed for 2 weeks under 40°C/75% RH open dish conditions and the crystalline API form did not change upon storage. Overall, the processing windows were established for the HPMC based HME-CR formulations.