An easy, facile and mild approach of liquid assisted grinding for the synthesis of novel dihydrobenzo[f]pyrano[3,2-c]chromenone derivatives using multicomponent cascade is herein described. The advantages of this protocol is one pot strategy, high reaction throughput, excellent yields, diversified scope, excellent score of green matrices. In addition, synthesis of bis (benzo[f]chromen-3-one) derivatives under microwave irradiation have also been established. The current methods utilize DABCO as a catalyst in forging these bioactive molecules. Also, all the final products are obtained by mere filtration, and the reaction conditions do not require any harsh reagents or typical work up.

A catalytic enantioselective protocol for the synthesis of aryl−methyl organophosphorus compounds is reported. Utilizing a chiral phosphoric acid as a catalyst, a wide range of indole derivatives reacted with phosphorylated quinomethanes in high yield with excellent enantioselectivity. This is the first report on the application of phosphorylated quinomethanes in asymmetric synthesis.

A multicomponent one-pot domino reaction of 1-hydroxy-3Hbenzo[f]chromen-3-one, isatin and malononitrile/ethyl cyanoacetate is herein investigated. The methodology concludes to synthesize diversified novel spiro-benzo[f]pyranochromene derivatives in good to excellent yields. This method is compatible with different unsubstituted and substituted isatins bearing electron-donating and electron-withdrawing groups. The operational simplicity, short reaction time along with the gram scale up protocol make this synthetic process suitable for both academia as well as industry.