Introduction: Multimorbidity is increasingly recognized as a key issue in the prevention and management of chronic diseases. We examined the prevalence and correlates of chronic disease multimorbidity in the general adult Canadian population in relation to age and other key determinants.

Background: An emerging literature suggests that environmental chemicals may play a role in the development of childhood obesity and metabolic disorders, especially when exposure occurs early in life.Objective: Here we assess the association between these health outcomes and exposure to maternal smoking during pregnancy as part of a broader effort to develop a research agenda to better understand the role of environmental chemicals as potential risk factors for obesity and metabolic disorders.Methods: PubMed was searched up to 8 March 2012 for epidemiological and experimental animal studies related to maternal smoking or nicotine exposure during pregnancy and childhood obesity or metabolic disorders at any age. A total of 101 studies—83 in humans and 18 in animals—were identified as the primary literature.Discussion: Current epidemiological data support a positive association between maternal smoking and increased risk of obesity or overweight in offspring. The data strongly suggest a causal relation, although the possibility that the association is attributable to unmeasured residual confounding cannot be completely ruled out. This conclusion is supported by findings from laboratory animals exposed to nicotine during development. The existing literature on human exposures does not support an association between maternal smoking during pregnancy and type 1 diabetes in offspring. Too few human studies have assessed outcomes related to type 2 diabetes or metabolic syndrome to reach conclusions based on patterns of findings. There may be a number of mechanistic pathways important for the development of aberrant metabolic outcomes following perinatal exposure to cigarette smoke, which remain largely unexplored.Conclusions: From a toxicological perspective, the linkages between maternal smoking during pregnancy and childhood overweight/obesity provide proof-of-concept of how early-life exposure to an environmental toxicant can be a risk factor for childhood obesity.

Introduction Excess weight is a key risk factor for chronic disease, and the systematic collection, analysis and reporting of key trends are important to surveillance of overweight and obesity. Methods We used univariate analyses to calculate current prevalence estimates of excess weight among Canadian children and youth. Results Almost 1 in 7 children and youth is obese. Rates vary based on sociodemographic factors such as age, sex, socioeconomic status and place of residence. Overall, the rates of excess weight have been relatively stable over the past decade. Conclusion Ongoing monitoring of childhood obesity will provide useful information to assist with sustained actions to promote healthy weights.

Introduction Geographical positioning systems (GPS) have the capacity to provide further context around where physical activity (PA) and sedentary time (ST) are accrued especially when overlaid onto objectively measured movement. The objective of this rapid review was to summarize evidence from location-based studies which employed the simultaneous use of GPS and objective measures of PA and/or ST. Methods Six databases were searched to identify studies that employed the simultaneous use of GPS and objective measures of PA or ST to quantify location of movement. Risk of bias was assessed, and a qualitative synthesis completed. Results Searching identified 3446 articles; 59 were included in the review. A total of 22 studies in children, 17 in youth and 20 in adults were captured. The active transportation environment emerged as an important location for moderate-to-vigorous intensity physical activity (MVPA) in children, youth and adults. In children and youth, the school is an important location for MVPA, especially the schoolyard for children. Indoor locations (e.g., schools, homes) appear to be greater sources of lighter intensities of PA and ST. The review was limited by a lack of standardization in the nomenclature used to describe the locations and methods, as well as measures of variance. Conclusion Evidence suggests that the active transportation environment is a potentially important contributor of MVPA across an individual’s lifespan. There is a need for future location-based studies to report on locations of all intensity of movement (including minutes and proportion) using a whole-day approach in larger representative samples.