No abstract

Oral cancers are considered slow killer disease. Every year 3,00,000 cases are diagnosed worldwide. Public awareness has been a great challenge to educate people to avoid harmful oral habits to prevent oral cancer. People are not aware about life threatening complications such as death due to oral cancer. Oral cancer is the eighth most common malignancy in India and third most common malignancy in South East Asia. Buccal mucosa carcinoma spreads rapidly and invades deeply to underlying tissues and has high recurrence rate. Surgical resection is more challenging if the tumour invade adjacent anatomical structures and reconstruction should be planned according to extent of tumour resection. Regional flaps are used for oral cavity after tumour resection such as radial forearm flap, deltopectoral flap, pectoralis major flap, latissimus dorsi flap, transverse rectus abdominis myocutaneous flap, trapezius flap. In this case report folded forehead pedicle flap was used to provide both inner and outer linings of the cheek defect following buccal mucosa tumour resection.

Background: Corona virus disease (COVID 19) has been emerging as a major threat to humans all over the world. Severe Acute Respiratory Syndrome CoronaVirus 2 (nSARSCoV2) is the causative agent for the disease resulting in severe acute respiratory illness.Earlier, it took several years to come with vaccine or other sort of treatments for viral diseases.But now with the advent of biotechnology and development of bio-informatic tools, the process has been accelerated. WHO reports 39,806,488 affected cases and 1,112,208 deaths till today all over the world (17 Oct 2020). nSARS CoV2 has greater influence on people with comorbidities mainly cancer. Objective: The study here attempts to understand the binding affinity of the spike protein of the novel corona virus with the lung and breast cancer marker proteins by docking and cluspro analysis. Method: This is done in reference to hACE2 (human Angiotensin Converting Enzyme 2), the receptor of nSARS CoV2. Of the 22 different marker proteins analyzed using cluspro. Results: BRCA1 (Breast Cancer type 1 susceptibility protein) and CXCR4 (a chemokine receptor belongs to G protein coupled receptor family) were found to exhibit higher binding affinities.-73.82 kcal/mol and -66.45 kcal/mol were the global energies they showed upon binding to S protein respectively. Conclusion: Therefore, novel SARSCoV2 has a higher chance of inducing cancer in non-cancerous individuals and aids in cancer acceleration in cancerous individuals.This poses a threat to cancer patients and immuno compromised individuals. The study can be exploited to identify the optimal drug delivery system for novel SARS CoV2.