Aim: To study the skin disease in patients with central nervous system (CNS) disorders. Methods: Total 78 patients of CNS disorders were studied, among which 49 (62.82%) patients had skin lesions. Maximum number of patients with skin lesions had paraplegia, followed by epilepsy. Dermatophytosis was the commonest dermatosis found in 24.48% of patients followed by seborrhoeic dermatitis in 14.28% patients. Conclusion: Dermatosis in CNS disorders may be due to its treatment, immobility, congenital defects, or their common ectodermal origin.