No abstract

The purpose of this study was aimed to investigate the zinc oxide nanoparticles (ZnONPs) synthesizing efficiency of aqueous leaf extract of Phyllanthus acidus. Furthermore, the antioxidant and anticancer activities of synthesized ZnONPs were also investigated through the in-vitro approach. The obtained results show that the aqueous extract of P. acidus can synthesize ZnONPs, as evidenced by a sharp absorbance peak at 375 nm. The Fourier transform infrared spectroscopy (FTIR) analysis confirmed that the aqueous extract contained significant numbers of functional groups, which were involved in reducing zinc nitrate into ZnONPs. Also, they participate in the capping and stabilization of synthesized ZnONPs and their size ranged from 27.14–35.74 nm with a spherical shape . The results obtained in ABTS radical scavenging activity 1, 1-diphenyl-2-picryl-hydroxyl (DPPH), hydrogen peroxide (H2O2), and 2,2′-Azino-Bis(3-ethylbenzene thiazoline-6-sulfonic acid) (ABTS) assays declared has excellent in-vitro radicals scavenging activity with reasonable IC50 values. Interestingly, these green synthesized ZnONPs have an excellent anticancer activity against human epidermoid carcinoma (Hep3) cell line in an in-vitro approach. These findings imply that an aqueous leaf extract of P. acidus can be used to synthesize pharmaceutically valuable ZnONPs. To consider such nanomaterials as potential therapeutic agents, optimization and in-vivo biomedical studies are required.

Nanomaterials are increasingly being used in pharmaceutical industry to treat a variety of disorders and diseases. Hence, the aim of this research was to evaluate their antioxidant and anticancer activity of presynthesized and characterized plant-based AgNPs against ferric, DPPH, H2O2, and ABTS free radicals and MCF-7 cell line. Interestingly, the antioxidants assay results revealed that the increased concentration (100 μg mL-1) of AgNPs has remarkable antioxidant ability on ferric (78.20%), DPPH (89.61%), H2O2 (82.34%), and ABTS (67.95%) free radicals. These scavenging activities were almost close to the free radicals scavenging ability of vitamin C (ascorbic acid). Similarly, test AgNPs showed considerable cytotoxicity (83.15%) against MCF-7 cell line, and it was partially comparable with the cytotoxicity activity (91.35%) of positive control (Doxorubicin). These findings indicate that plant-mediated AgNPs have significant antioxidant and anticancer activity, and thus may be considered for biomedical applications pending the results of some in vivo experiments.